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Genes within 1Mb (chr1:65699594:T:C):

View on , UCSC , GTEx , gnomAD

Immune cell-type specific single cell cis-eQTLs in OASIS
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 631840 sc-eQTL 3.78e-01 -0.0541 0.0612 0.265 B L1
ENSG00000184588 PDE4B -92920 sc-eQTL 8.89e-02 -0.109 0.0636 0.265 B L1
ENSG00000213625 LEPROT 279007 sc-eQTL 5.17e-01 -0.0508 0.0782 0.265 B L1
ENSG00000162434 JAK1 631840 sc-eQTL 9.51e-02 -0.0992 0.0592 0.265 CD4T L1
ENSG00000184588 PDE4B -92920 sc-eQTL 6.27e-01 -0.0345 0.071 0.265 CD4T L1
ENSG00000213625 LEPROT 279007 sc-eQTL 2.49e-02 -0.208 0.0921 0.265 CD4T L1
ENSG00000116678 LEPR 278942 sc-eQTL 2.76e-02 -0.22 0.0992 0.265 CD8T L1
ENSG00000162434 JAK1 631840 sc-eQTL 6.14e-01 -0.0393 0.0778 0.265 CD8T L1
ENSG00000184588 PDE4B -92920 sc-eQTL 8.71e-02 -0.113 0.0659 0.265 CD8T L1
ENSG00000213625 LEPROT 279007 sc-eQTL 4.90e-01 -0.0712 0.103 0.265 CD8T L1
ENSG00000116678 LEPR 278942 sc-eQTL 5.66e-01 0.0604 0.105 0.268 DC L1
ENSG00000162433 AK4 552045 sc-eQTL 1.13e-01 0.14 0.0879 0.268 DC L1
ENSG00000162434 JAK1 631840 sc-eQTL 7.51e-01 -0.0234 0.0735 0.268 DC L1
ENSG00000162437 RAVER2 954499 sc-eQTL 8.49e-01 -0.0179 0.0942 0.268 DC L1
ENSG00000184588 PDE4B -92920 sc-eQTL 2.62e-01 -0.064 0.0568 0.268 DC L1
ENSG00000213625 LEPROT 279007 sc-eQTL 9.87e-01 0.00164 0.104 0.268 DC L1
ENSG00000285079 AL513493.1 -4368 sc-eQTL 1.52e-04 0.209 0.0542 0.268 DC L1
ENSG00000116678 LEPR 278942 sc-eQTL 3.76e-01 -0.0895 0.101 0.265 Mono L1
ENSG00000162433 AK4 552045 sc-eQTL 9.98e-01 0.000257 0.0925 0.265 Mono L1
ENSG00000162434 JAK1 631840 sc-eQTL 8.70e-01 0.0108 0.066 0.265 Mono L1
ENSG00000184588 PDE4B -92920 sc-eQTL 7.00e-01 -0.0141 0.0365 0.265 Mono L1
ENSG00000213625 LEPROT 279007 sc-eQTL 3.20e-01 -0.065 0.0652 0.265 Mono L1
ENSG00000116678 LEPR 278942 sc-eQTL 5.26e-01 0.0628 0.0989 0.264 NK L1
ENSG00000162434 JAK1 631840 sc-eQTL 3.73e-01 -0.0417 0.0467 0.264 NK L1
ENSG00000184588 PDE4B -92920 sc-eQTL 4.02e-03 -0.182 0.0626 0.264 NK L1
ENSG00000213625 LEPROT 279007 sc-eQTL 7.60e-01 -0.0326 0.107 0.264 NK L1
ENSG00000162434 JAK1 631840 sc-eQTL 1.71e-01 0.0926 0.0674 0.265 Other_T L1
ENSG00000162437 RAVER2 954499 sc-eQTL 4.47e-01 0.0748 0.0983 0.265 Other_T L1
ENSG00000184588 PDE4B -92920 sc-eQTL 8.05e-02 -0.128 0.073 0.265 Other_T L1
ENSG00000213625 LEPROT 279007 sc-eQTL 9.63e-01 -0.00492 0.106 0.265 Other_T L1
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 631840 sc-eQTL 3.22e-01 0.111 0.111 0.24 B_Activated L2
ENSG00000184588 PDE4B -92920 sc-eQTL 6.99e-03 -0.237 0.0868 0.24 B_Activated L2
ENSG00000213625 LEPROT 279007 sc-eQTL 1.42e-01 -0.171 0.116 0.24 B_Activated L2
ENSG00000162434 JAK1 631840 sc-eQTL 9.78e-01 0.00247 0.0874 0.264 B_Intermediate L2
ENSG00000184588 PDE4B -92920 sc-eQTL 3.77e-01 -0.063 0.0711 0.264 B_Intermediate L2
ENSG00000213625 LEPROT 279007 sc-eQTL 8.16e-01 0.0238 0.102 0.264 B_Intermediate L2
ENSG00000162434 JAK1 631840 sc-eQTL 7.04e-01 0.0334 0.0877 0.267 B_Memory L2
ENSG00000184588 PDE4B -92920 sc-eQTL 1.63e-01 -0.125 0.0893 0.267 B_Memory L2
ENSG00000213625 LEPROT 279007 sc-eQTL 7.31e-01 -0.035 0.102 0.267 B_Memory L2
ENSG00000162434 JAK1 631840 sc-eQTL 9.84e-01 0.00155 0.078 0.265 B_Naive1 L2
ENSG00000184588 PDE4B -92920 sc-eQTL 3.54e-02 -0.158 0.0744 0.265 B_Naive1 L2
ENSG00000213625 LEPROT 279007 sc-eQTL 5.47e-01 -0.0613 0.102 0.265 B_Naive1 L2
ENSG00000162434 JAK1 631840 sc-eQTL 3.24e-01 -0.0808 0.0816 0.266 B_Naive2 L2
ENSG00000184588 PDE4B -92920 sc-eQTL 4.80e-02 -0.127 0.0641 0.266 B_Naive2 L2
ENSG00000213625 LEPROT 279007 sc-eQTL 8.40e-01 -0.02 0.0987 0.266 B_Naive2 L2
ENSG00000162434 JAK1 631840 sc-eQTL 1.80e-01 -0.129 0.0962 0.264 CD4_CTL L2
ENSG00000184588 PDE4B -92920 sc-eQTL 2.01e-02 -0.198 0.0843 0.264 CD4_CTL L2
ENSG00000213625 LEPROT 279007 sc-eQTL 4.22e-01 -0.0892 0.111 0.264 CD4_CTL L2
ENSG00000162434 JAK1 631840 sc-eQTL 1.17e-01 -0.0918 0.0583 0.265 CD4_Naive L2
ENSG00000184588 PDE4B -92920 sc-eQTL 9.41e-01 -0.00541 0.0733 0.265 CD4_Naive L2
ENSG00000213625 LEPROT 279007 sc-eQTL 1.08e-01 -0.152 0.0945 0.265 CD4_Naive L2
ENSG00000162434 JAK1 631840 sc-eQTL 2.83e-01 -0.072 0.0668 0.265 CD4_TCM L2
ENSG00000184588 PDE4B -92920 sc-eQTL 4.76e-02 -0.151 0.076 0.265 CD4_TCM L2
ENSG00000213625 LEPROT 279007 sc-eQTL 3.70e-02 -0.202 0.0962 0.265 CD4_TCM L2
ENSG00000162434 JAK1 631840 sc-eQTL 5.93e-01 0.0484 0.0905 0.265 CD4_TEM L2
ENSG00000184588 PDE4B -92920 sc-eQTL 2.68e-01 -0.0927 0.0834 0.265 CD4_TEM L2
ENSG00000213625 LEPROT 279007 sc-eQTL 2.19e-01 -0.132 0.107 0.265 CD4_TEM L2
ENSG00000116678 LEPR 278942 sc-eQTL 1.17e-01 -0.154 0.098 0.265 CD8_CTL L2
ENSG00000162434 JAK1 631840 sc-eQTL 9.40e-01 -0.00624 0.0828 0.265 CD8_CTL L2
ENSG00000184588 PDE4B -92920 sc-eQTL 3.57e-03 -0.221 0.075 0.265 CD8_CTL L2
ENSG00000213625 LEPROT 279007 sc-eQTL 6.17e-02 -0.188 0.1 0.265 CD8_CTL L2
ENSG00000116678 LEPR 278942 sc-eQTL 4.56e-01 -0.0746 0.0998 0.265 CD8_Naive L2
ENSG00000162434 JAK1 631840 sc-eQTL 4.07e-01 -0.0692 0.0832 0.265 CD8_Naive L2
ENSG00000184588 PDE4B -92920 sc-eQTL 4.33e-01 -0.055 0.0699 0.265 CD8_Naive L2
ENSG00000213625 LEPROT 279007 sc-eQTL 3.00e-01 0.106 0.102 0.265 CD8_Naive L2
ENSG00000116678 LEPR 278942 sc-eQTL 4.17e-01 -0.0825 0.101 0.264 CD8_TCM L2
ENSG00000162434 JAK1 631840 sc-eQTL 8.43e-01 -0.0175 0.0882 0.264 CD8_TCM L2
ENSG00000184588 PDE4B -92920 sc-eQTL 9.28e-01 -0.00881 0.0971 0.264 CD8_TCM L2
ENSG00000213625 LEPROT 279007 sc-eQTL 9.32e-01 0.00934 0.11 0.264 CD8_TCM L2
ENSG00000116678 LEPR 278942 sc-eQTL 6.68e-01 -0.0403 0.0938 0.263 CD8_TEM L2
ENSG00000162434 JAK1 631840 sc-eQTL 2.06e-02 -0.244 0.105 0.263 CD8_TEM L2
ENSG00000184588 PDE4B -92920 sc-eQTL 9.28e-02 -0.151 0.0896 0.263 CD8_TEM L2
ENSG00000213625 LEPROT 279007 sc-eQTL 6.79e-01 0.0453 0.109 0.263 CD8_TEM L2
ENSG00000162434 JAK1 631840 sc-eQTL 6.83e-01 0.0376 0.092 0.262 MAIT L2
ENSG00000162437 RAVER2 954499 sc-eQTL 5.23e-01 0.0627 0.098 0.262 MAIT L2
ENSG00000184588 PDE4B -92920 sc-eQTL 3.42e-02 -0.166 0.0779 0.262 MAIT L2
ENSG00000213625 LEPROT 279007 sc-eQTL 8.96e-01 -0.0139 0.106 0.262 MAIT L2
ENSG00000116678 LEPR 278942 sc-eQTL 3.86e-02 0.199 0.0958 0.264 NK_CD56bright L2
ENSG00000162434 JAK1 631840 sc-eQTL 5.56e-01 0.0391 0.0663 0.264 NK_CD56bright L2
ENSG00000184588 PDE4B -92920 sc-eQTL 4.51e-03 -0.224 0.078 0.264 NK_CD56bright L2
ENSG00000213625 LEPROT 279007 sc-eQTL 9.51e-01 -0.00666 0.109 0.264 NK_CD56bright L2
ENSG00000116678 LEPR 278942 sc-eQTL 6.14e-01 0.0531 0.105 0.261 NK_CD56dim L2
ENSG00000162434 JAK1 631840 sc-eQTL 2.05e-01 -0.0698 0.0549 0.261 NK_CD56dim L2
ENSG00000184588 PDE4B -92920 sc-eQTL 3.12e-01 -0.0812 0.0802 0.261 NK_CD56dim L2
ENSG00000213625 LEPROT 279007 sc-eQTL 4.90e-01 -0.077 0.111 0.261 NK_CD56dim L2
ENSG00000116678 LEPR 278942 sc-eQTL 9.39e-02 -0.154 0.0915 0.256 NK_HLA L2
ENSG00000162434 JAK1 631840 sc-eQTL 9.40e-02 0.12 0.0712 0.256 NK_HLA L2
ENSG00000184588 PDE4B -92920 sc-eQTL 9.95e-02 -0.144 0.0867 0.256 NK_HLA L2
ENSG00000213625 LEPROT 279007 sc-eQTL 5.44e-01 -0.0675 0.111 0.256 NK_HLA L2
ENSG00000116678 LEPR 278942 sc-eQTL 9.54e-01 0.00579 0.101 0.261 NK_cytokine L2
ENSG00000162434 JAK1 631840 sc-eQTL 9.34e-01 0.00483 0.0585 0.261 NK_cytokine L2
ENSG00000184588 PDE4B -92920 sc-eQTL 8.74e-03 -0.239 0.0903 0.261 NK_cytokine L2
ENSG00000213625 LEPROT 279007 sc-eQTL 1.68e-01 0.147 0.106 0.261 NK_cytokine L2
ENSG00000162434 JAK1 631840 sc-eQTL 4.10e-01 -0.0818 0.0989 0.252 PB L2
ENSG00000184588 PDE4B -92920 sc-eQTL 5.69e-01 0.0718 0.126 0.252 PB L2
ENSG00000213625 LEPROT 279007 sc-eQTL 4.30e-01 0.11 0.139 0.252 PB L2
ENSG00000162434 JAK1 631840 sc-eQTL 1.88e-01 0.0879 0.0665 0.265 Pro_T L2
ENSG00000162437 RAVER2 954499 sc-eQTL 9.01e-01 -0.011 0.0881 0.265 Pro_T L2
ENSG00000184588 PDE4B -92920 sc-eQTL 9.95e-01 0.000533 0.082 0.265 Pro_T L2
ENSG00000213625 LEPROT 279007 sc-eQTL 8.43e-01 -0.0206 0.104 0.265 Pro_T L2
ENSG00000162434 JAK1 631840 sc-eQTL 2.28e-01 0.102 0.084 0.265 Treg L2
ENSG00000184588 PDE4B -92920 sc-eQTL 8.15e-01 -0.0181 0.0769 0.265 Treg L2
ENSG00000213625 LEPROT 279007 sc-eQTL 6.16e-01 0.0549 0.109 0.265 Treg L2
ENSG00000116678 LEPR 278942 sc-eQTL 6.51e-01 0.0482 0.107 0.259 cDC L2
ENSG00000162433 AK4 552045 sc-eQTL 2.92e-01 0.0992 0.0939 0.259 cDC L2
ENSG00000162434 JAK1 631840 sc-eQTL 7.36e-01 -0.0297 0.0879 0.259 cDC L2
ENSG00000162437 RAVER2 954499 sc-eQTL 7.53e-01 -0.0305 0.0965 0.259 cDC L2
ENSG00000184588 PDE4B -92920 sc-eQTL 5.79e-01 -0.0327 0.0589 0.259 cDC L2
ENSG00000213625 LEPROT 279007 sc-eQTL 8.47e-01 -0.0207 0.107 0.259 cDC L2
ENSG00000285079 AL513493.1 -4368 sc-eQTL 7.83e-01 -0.0106 0.0385 0.259 cDC L2
ENSG00000116678 LEPR 278942 sc-eQTL 2.18e-01 -0.126 0.102 0.265 cMono_IL1B L2
ENSG00000162433 AK4 552045 sc-eQTL 1.77e-01 -0.127 0.0935 0.265 cMono_IL1B L2
ENSG00000162434 JAK1 631840 sc-eQTL 9.42e-01 -0.00617 0.0854 0.265 cMono_IL1B L2
ENSG00000184588 PDE4B -92920 sc-eQTL 7.81e-01 -0.0132 0.0473 0.265 cMono_IL1B L2
ENSG00000213625 LEPROT 279007 sc-eQTL 7.47e-01 0.0223 0.069 0.265 cMono_IL1B L2
ENSG00000116678 LEPR 278942 sc-eQTL 8.46e-01 0.0195 0.1 0.265 cMono_S100A L2
ENSG00000162433 AK4 552045 sc-eQTL 9.34e-01 0.00787 0.0951 0.265 cMono_S100A L2
ENSG00000162434 JAK1 631840 sc-eQTL 6.73e-01 -0.0371 0.0878 0.265 cMono_S100A L2
ENSG00000184588 PDE4B -92920 sc-eQTL 5.33e-01 -0.031 0.0496 0.265 cMono_S100A L2
ENSG00000213625 LEPROT 279007 sc-eQTL 4.48e-02 -0.164 0.0813 0.265 cMono_S100A L2
ENSG00000162434 JAK1 631840 sc-eQTL 6.68e-01 0.055 0.128 0.258 gdT L2
ENSG00000162437 RAVER2 954499 sc-eQTL 7.43e-01 -0.037 0.113 0.258 gdT L2
ENSG00000184588 PDE4B -92920 sc-eQTL 4.97e-01 -0.0506 0.0744 0.258 gdT L2
ENSG00000213625 LEPROT 279007 sc-eQTL 6.28e-01 -0.0656 0.135 0.258 gdT L2
ENSG00000116678 LEPR 278942 sc-eQTL 9.58e-01 -0.00539 0.101 0.258 intMono L2
ENSG00000162433 AK4 552045 sc-eQTL 5.37e-01 0.059 0.0954 0.258 intMono L2
ENSG00000162434 JAK1 631840 sc-eQTL 3.36e-02 0.187 0.0874 0.258 intMono L2
ENSG00000184588 PDE4B -92920 sc-eQTL 7.21e-01 -0.0183 0.051 0.258 intMono L2
ENSG00000213625 LEPROT 279007 sc-eQTL 2.68e-01 -0.0942 0.0849 0.258 intMono L2
ENSG00000116678 LEPR 278942 sc-eQTL 4.82e-01 -0.0703 0.0998 0.253 ncMono L2
ENSG00000162433 AK4 552045 sc-eQTL 3.13e-02 0.191 0.0881 0.253 ncMono L2
ENSG00000162434 JAK1 631840 sc-eQTL 6.15e-02 -0.134 0.0715 0.253 ncMono L2
ENSG00000184588 PDE4B -92920 sc-eQTL 5.96e-01 -0.0304 0.0572 0.253 ncMono L2
ENSG00000213625 LEPROT 279007 sc-eQTL 2.64e-01 -0.114 0.102 0.253 ncMono L2
ENSG00000116678 LEPR 278942 sc-eQTL 1.70e-01 0.141 0.102 0.263 pDC L2
ENSG00000162433 AK4 552045 sc-eQTL 8.33e-01 -0.0142 0.0671 0.263 pDC L2
ENSG00000162434 JAK1 631840 sc-eQTL 6.47e-01 -0.0411 0.0895 0.263 pDC L2
ENSG00000162437 RAVER2 954499 sc-eQTL 9.48e-01 0.00654 0.101 0.263 pDC L2
ENSG00000184588 PDE4B -92920 sc-eQTL 5.32e-01 -0.0489 0.0781 0.263 pDC L2
ENSG00000213625 LEPROT 279007 sc-eQTL 1.68e-01 -0.153 0.11 0.263 pDC L2
ENSG00000285079 AL513493.1 -4368 sc-eQTL 3.87e-04 0.292 0.0806 0.263 pDC L2
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 631840 sc-eQTL 8.34e-01 -0.0164 0.0782 0.265 B_Memory LOneK1K
ENSG00000184588 PDE4B -92920 sc-eQTL 9.68e-02 -0.107 0.0638 0.265 B_Memory LOneK1K
ENSG00000213625 LEPROT 279007 sc-eQTL 7.50e-01 -0.0321 0.1 0.265 B_Memory LOneK1K
ENSG00000162434 JAK1 631840 sc-eQTL 6.14e-01 -0.0381 0.0754 0.265 B_Naive LOneK1K
ENSG00000184588 PDE4B -92920 sc-eQTL 2.05e-02 -0.156 0.0669 0.265 B_Naive LOneK1K
ENSG00000213625 LEPROT 279007 sc-eQTL 4.22e-01 -0.0767 0.0953 0.265 B_Naive LOneK1K
ENSG00000116678 LEPR 278942 sc-eQTL 3.52e-01 -0.0932 0.0998 0.265 CD14_Mono LOneK1K
ENSG00000162433 AK4 552045 sc-eQTL 6.42e-01 -0.0445 0.0956 0.265 CD14_Mono LOneK1K
ENSG00000162434 JAK1 631840 sc-eQTL 8.34e-01 0.0168 0.0801 0.265 CD14_Mono LOneK1K
ENSG00000184588 PDE4B -92920 sc-eQTL 4.66e-01 -0.0298 0.0408 0.265 CD14_Mono LOneK1K
ENSG00000213625 LEPROT 279007 sc-eQTL 6.81e-01 -0.0277 0.0671 0.265 CD14_Mono LOneK1K
ENSG00000116678 LEPR 278942 sc-eQTL 4.12e-01 -0.0833 0.101 0.263 CD16_Mono LOneK1K
ENSG00000162433 AK4 552045 sc-eQTL 5.64e-01 0.0531 0.0918 0.263 CD16_Mono LOneK1K
ENSG00000162434 JAK1 631840 sc-eQTL 8.86e-01 0.00889 0.0618 0.263 CD16_Mono LOneK1K
ENSG00000184588 PDE4B -92920 sc-eQTL 5.92e-01 -0.0254 0.0472 0.263 CD16_Mono LOneK1K
ENSG00000213625 LEPROT 279007 sc-eQTL 3.28e-02 -0.183 0.0853 0.263 CD16_Mono LOneK1K
ENSG00000116678 LEPR 278942 sc-eQTL 7.09e-01 0.0382 0.102 0.261 NK_CD56dim LOneK1K
ENSG00000162434 JAK1 631840 sc-eQTL 3.51e-01 -0.0447 0.0478 0.261 NK_CD56dim LOneK1K
ENSG00000184588 PDE4B -92920 sc-eQTL 3.49e-02 -0.156 0.0735 0.261 NK_CD56dim LOneK1K
ENSG00000213625 LEPROT 279007 sc-eQTL 9.67e-01 0.00445 0.106 0.261 NK_CD56dim LOneK1K

Statistical fine-mapping results from Japan COVID-19 Task Force
(Shown only for PIP>0.001)
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
PIP (SuSiE)
PIP (FINEMAP)
MAF
ENSG00000116675 DNAJC6 451375 eQTL 0.0207 0.0756 0.0326 0.00134 0.0 0.295
ENSG00000116678 LEPR 278942 eQTL 0.195 0.032 0.0247 0.0132 0.0093 0.295

Expression Modifier Score(EMS) for GTEx 49tissues
Gene ID
Gene Symbol
TSS Distance
Whole Blood
Muscle Skeletal
Liver
Brain Cerebellum
Prostate
Spleen
Skin Sun Exposed Lower leg
Artery Coronary
Esophagus Muscularis
Esophagus Gastroesophageal Junction
Artery Tibial
Heart Atrial Appendage
Nerve Tibial
Heart Left Ventricle
Adrenal Gland
Adipose Visceral Omentum
Pancreas
Lung
Pituitary
Brain Nucleus accumbens basal ganglia
Colon Transverse
Adipose Subcutaneous
Esophagus Mucosa
Brain Cortex
Thyroid
Stomach
Breast Mammary Tissue
Colon Sigmoid
Skin Not Sun Exposed Suprapubic
Testis
Artery Aorta
Brain Amygdala
Brain Anterior cingulate cortex BA24
Brain Caudate basal ganglia
Brain Cerebellar Hemisphere
Brain Frontal Cortex BA9
Brain Hippocampus
Brain Hypothalamus
Brain Putamen basal ganglia
Brain Spinal cord cervical c-1
Brain Substantia nigra
Cells Cultured fibroblasts
Cells EBV-transformed lymphocytes
Kidney Cortex
Minor Salivary Gland
Ovary
Small Intestine Terminal Ileum
Uterus
Vagina
ENSG00000116675 DNAJC6 451375 5.14e-07 2.89e-07 7.87e-08 2.92e-07 1.05e-07 1.28e-07 3.94e-07 8.37e-08 2.76e-07 1.7e-07 3.92e-07 2.09e-07 4.88e-07 8.85e-08 1.24e-07 1.53e-07 1.01e-07 2.93e-07 9.97e-08 8.1e-08 1.57e-07 2.48e-07 2.63e-07 7.36e-08 4.54e-07 2.13e-07 1.74e-07 1.86e-07 2.19e-07 2.59e-07 1.95e-07 5.22e-08 5.75e-08 1.17e-07 1.33e-07 5.2e-08 7.74e-08 5.71e-08 5.98e-08 7.5e-08 4.63e-08 3.27e-07 3.4e-08 1.74e-08 8.43e-08 8.59e-09 9.38e-08 0.0 4.82e-08