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Genes within 1Mb (chr1:65696948:A:C):

View on , UCSC , GTEx , gnomAD

Immune cell-type specific single cell cis-eQTLs in OASIS
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 629194 sc-eQTL 3.56e-01 -0.0567 0.0613 0.263 B L1
ENSG00000184588 PDE4B -95566 sc-eQTL 6.68e-02 -0.117 0.0636 0.263 B L1
ENSG00000213625 LEPROT 276361 sc-eQTL 7.25e-01 -0.0276 0.0784 0.263 B L1
ENSG00000162434 JAK1 629194 sc-eQTL 1.17e-01 -0.093 0.0592 0.263 CD4T L1
ENSG00000184588 PDE4B -95566 sc-eQTL 6.19e-01 -0.0353 0.0709 0.263 CD4T L1
ENSG00000213625 LEPROT 276361 sc-eQTL 5.56e-02 -0.178 0.0922 0.263 CD4T L1
ENSG00000116678 LEPR 276296 sc-eQTL 2.99e-02 -0.216 0.099 0.263 CD8T L1
ENSG00000162434 JAK1 629194 sc-eQTL 5.87e-01 -0.0422 0.0776 0.263 CD8T L1
ENSG00000184588 PDE4B -95566 sc-eQTL 8.34e-02 -0.114 0.0658 0.263 CD8T L1
ENSG00000213625 LEPROT 276361 sc-eQTL 5.62e-01 -0.0597 0.103 0.263 CD8T L1
ENSG00000116678 LEPR 276296 sc-eQTL 4.78e-01 0.0751 0.106 0.266 DC L1
ENSG00000162433 AK4 549399 sc-eQTL 1.46e-01 0.129 0.0884 0.266 DC L1
ENSG00000162434 JAK1 629194 sc-eQTL 5.37e-01 -0.0457 0.0738 0.266 DC L1
ENSG00000162437 RAVER2 951853 sc-eQTL 9.92e-01 0.000989 0.0947 0.266 DC L1
ENSG00000184588 PDE4B -95566 sc-eQTL 3.07e-01 -0.0585 0.0571 0.266 DC L1
ENSG00000213625 LEPROT 276361 sc-eQTL 7.78e-01 0.0296 0.105 0.266 DC L1
ENSG00000285079 AL513493.1 -7014 sc-eQTL 2.20e-04 0.205 0.0545 0.266 DC L1
ENSG00000116678 LEPR 276296 sc-eQTL 4.22e-01 -0.0811 0.101 0.263 Mono L1
ENSG00000162433 AK4 549399 sc-eQTL 9.77e-01 0.00267 0.0925 0.263 Mono L1
ENSG00000162434 JAK1 629194 sc-eQTL 9.55e-01 0.00375 0.066 0.263 Mono L1
ENSG00000184588 PDE4B -95566 sc-eQTL 8.00e-01 -0.00928 0.0365 0.263 Mono L1
ENSG00000213625 LEPROT 276361 sc-eQTL 3.75e-01 -0.058 0.0652 0.263 Mono L1
ENSG00000116678 LEPR 276296 sc-eQTL 5.37e-01 0.0612 0.0989 0.262 NK L1
ENSG00000162434 JAK1 629194 sc-eQTL 3.26e-01 -0.046 0.0467 0.262 NK L1
ENSG00000184588 PDE4B -95566 sc-eQTL 2.96e-03 -0.188 0.0625 0.262 NK L1
ENSG00000213625 LEPROT 276361 sc-eQTL 8.84e-01 -0.0156 0.107 0.262 NK L1
ENSG00000162434 JAK1 629194 sc-eQTL 2.15e-01 0.0839 0.0675 0.263 Other_T L1
ENSG00000162437 RAVER2 951853 sc-eQTL 5.75e-01 0.0553 0.0983 0.263 Other_T L1
ENSG00000184588 PDE4B -95566 sc-eQTL 8.06e-02 -0.128 0.073 0.263 Other_T L1
ENSG00000213625 LEPROT 276361 sc-eQTL 9.94e-01 0.000798 0.106 0.263 Other_T L1
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 629194 sc-eQTL 3.95e-01 0.0951 0.111 0.237 B_Activated L2
ENSG00000184588 PDE4B -95566 sc-eQTL 3.94e-03 -0.253 0.0865 0.237 B_Activated L2
ENSG00000213625 LEPROT 276361 sc-eQTL 1.78e-01 -0.157 0.116 0.237 B_Activated L2
ENSG00000162434 JAK1 629194 sc-eQTL 9.63e-01 -0.00401 0.0874 0.262 B_Intermediate L2
ENSG00000184588 PDE4B -95566 sc-eQTL 3.22e-01 -0.0705 0.071 0.262 B_Intermediate L2
ENSG00000213625 LEPROT 276361 sc-eQTL 7.29e-01 0.0355 0.102 0.262 B_Intermediate L2
ENSG00000162434 JAK1 629194 sc-eQTL 6.57e-01 0.039 0.0877 0.265 B_Memory L2
ENSG00000184588 PDE4B -95566 sc-eQTL 1.37e-01 -0.133 0.0892 0.265 B_Memory L2
ENSG00000213625 LEPROT 276361 sc-eQTL 7.74e-01 -0.0294 0.102 0.265 B_Memory L2
ENSG00000162434 JAK1 629194 sc-eQTL 9.39e-01 -0.00597 0.0779 0.263 B_Naive1 L2
ENSG00000184588 PDE4B -95566 sc-eQTL 2.50e-02 -0.168 0.0742 0.263 B_Naive1 L2
ENSG00000213625 LEPROT 276361 sc-eQTL 7.07e-01 -0.0382 0.102 0.263 B_Naive1 L2
ENSG00000162434 JAK1 629194 sc-eQTL 3.77e-01 -0.0723 0.0816 0.264 B_Naive2 L2
ENSG00000184588 PDE4B -95566 sc-eQTL 3.61e-02 -0.135 0.064 0.264 B_Naive2 L2
ENSG00000213625 LEPROT 276361 sc-eQTL 9.39e-01 -0.00753 0.0986 0.264 B_Naive2 L2
ENSG00000162434 JAK1 629194 sc-eQTL 2.25e-01 -0.117 0.0963 0.261 CD4_CTL L2
ENSG00000184588 PDE4B -95566 sc-eQTL 1.56e-02 -0.206 0.0843 0.261 CD4_CTL L2
ENSG00000213625 LEPROT 276361 sc-eQTL 4.80e-01 -0.0784 0.111 0.261 CD4_CTL L2
ENSG00000162434 JAK1 629194 sc-eQTL 1.48e-01 -0.0845 0.0582 0.263 CD4_Naive L2
ENSG00000184588 PDE4B -95566 sc-eQTL 9.57e-01 -0.00397 0.0731 0.263 CD4_Naive L2
ENSG00000213625 LEPROT 276361 sc-eQTL 1.80e-01 -0.127 0.0944 0.263 CD4_Naive L2
ENSG00000162434 JAK1 629194 sc-eQTL 2.95e-01 -0.0699 0.0666 0.263 CD4_TCM L2
ENSG00000184588 PDE4B -95566 sc-eQTL 3.59e-02 -0.16 0.0757 0.263 CD4_TCM L2
ENSG00000213625 LEPROT 276361 sc-eQTL 5.66e-02 -0.184 0.0961 0.263 CD4_TCM L2
ENSG00000162434 JAK1 629194 sc-eQTL 6.13e-01 0.0457 0.0903 0.263 CD4_TEM L2
ENSG00000184588 PDE4B -95566 sc-eQTL 2.12e-01 -0.104 0.0832 0.263 CD4_TEM L2
ENSG00000213625 LEPROT 276361 sc-eQTL 2.23e-01 -0.131 0.107 0.263 CD4_TEM L2
ENSG00000116678 LEPR 276296 sc-eQTL 1.04e-01 -0.16 0.0979 0.263 CD8_CTL L2
ENSG00000162434 JAK1 629194 sc-eQTL 9.46e-01 -0.00564 0.0827 0.263 CD8_CTL L2
ENSG00000184588 PDE4B -95566 sc-eQTL 3.00e-03 -0.225 0.0749 0.263 CD8_CTL L2
ENSG00000213625 LEPROT 276361 sc-eQTL 8.59e-02 -0.173 0.1 0.263 CD8_CTL L2
ENSG00000116678 LEPR 276296 sc-eQTL 5.13e-01 -0.0652 0.0996 0.263 CD8_Naive L2
ENSG00000162434 JAK1 629194 sc-eQTL 3.63e-01 -0.0756 0.0829 0.263 CD8_Naive L2
ENSG00000184588 PDE4B -95566 sc-eQTL 4.57e-01 -0.052 0.0698 0.263 CD8_Naive L2
ENSG00000213625 LEPROT 276361 sc-eQTL 2.68e-01 0.113 0.102 0.263 CD8_Naive L2
ENSG00000116678 LEPR 276296 sc-eQTL 4.75e-01 -0.0725 0.101 0.262 CD8_TCM L2
ENSG00000162434 JAK1 629194 sc-eQTL 9.13e-01 -0.00968 0.0882 0.262 CD8_TCM L2
ENSG00000184588 PDE4B -95566 sc-eQTL 9.64e-01 -0.00442 0.0971 0.262 CD8_TCM L2
ENSG00000213625 LEPROT 276361 sc-eQTL 9.76e-01 -0.00332 0.11 0.262 CD8_TCM L2
ENSG00000116678 LEPR 276296 sc-eQTL 7.59e-01 -0.0289 0.0938 0.26 CD8_TEM L2
ENSG00000162434 JAK1 629194 sc-eQTL 2.16e-02 -0.242 0.105 0.26 CD8_TEM L2
ENSG00000184588 PDE4B -95566 sc-eQTL 8.61e-02 -0.154 0.0895 0.26 CD8_TEM L2
ENSG00000213625 LEPROT 276361 sc-eQTL 5.79e-01 0.0606 0.109 0.26 CD8_TEM L2
ENSG00000162434 JAK1 629194 sc-eQTL 6.76e-01 0.0384 0.0918 0.26 MAIT L2
ENSG00000162437 RAVER2 951853 sc-eQTL 4.88e-01 0.0679 0.0977 0.26 MAIT L2
ENSG00000184588 PDE4B -95566 sc-eQTL 4.19e-02 -0.159 0.0777 0.26 MAIT L2
ENSG00000213625 LEPROT 276361 sc-eQTL 9.06e-01 -0.0125 0.106 0.26 MAIT L2
ENSG00000116678 LEPR 276296 sc-eQTL 3.52e-02 0.203 0.0955 0.262 NK_CD56bright L2
ENSG00000162434 JAK1 629194 sc-eQTL 5.51e-01 0.0395 0.0661 0.262 NK_CD56bright L2
ENSG00000184588 PDE4B -95566 sc-eQTL 3.61e-03 -0.229 0.0777 0.262 NK_CD56bright L2
ENSG00000213625 LEPROT 276361 sc-eQTL 9.06e-01 0.0129 0.109 0.262 NK_CD56bright L2
ENSG00000116678 LEPR 276296 sc-eQTL 6.06e-01 0.0544 0.105 0.259 NK_CD56dim L2
ENSG00000162434 JAK1 629194 sc-eQTL 1.99e-01 -0.0705 0.0548 0.259 NK_CD56dim L2
ENSG00000184588 PDE4B -95566 sc-eQTL 2.76e-01 -0.0875 0.0801 0.259 NK_CD56dim L2
ENSG00000213625 LEPROT 276361 sc-eQTL 5.33e-01 -0.0695 0.111 0.259 NK_CD56dim L2
ENSG00000116678 LEPR 276296 sc-eQTL 1.23e-01 -0.142 0.0914 0.253 NK_HLA L2
ENSG00000162434 JAK1 629194 sc-eQTL 1.13e-01 0.113 0.0712 0.253 NK_HLA L2
ENSG00000184588 PDE4B -95566 sc-eQTL 9.80e-02 -0.144 0.0866 0.253 NK_HLA L2
ENSG00000213625 LEPROT 276361 sc-eQTL 6.73e-01 -0.047 0.111 0.253 NK_HLA L2
ENSG00000116678 LEPR 276296 sc-eQTL 9.51e-01 -0.00623 0.101 0.259 NK_cytokine L2
ENSG00000162434 JAK1 629194 sc-eQTL 9.49e-01 0.00377 0.0585 0.259 NK_cytokine L2
ENSG00000184588 PDE4B -95566 sc-eQTL 8.45e-03 -0.24 0.0902 0.259 NK_cytokine L2
ENSG00000213625 LEPROT 276361 sc-eQTL 1.55e-01 0.151 0.106 0.259 NK_cytokine L2
ENSG00000162434 JAK1 629194 sc-eQTL 5.48e-01 -0.0601 0.0997 0.248 PB L2
ENSG00000184588 PDE4B -95566 sc-eQTL 5.78e-01 0.0706 0.127 0.248 PB L2
ENSG00000213625 LEPROT 276361 sc-eQTL 3.71e-01 0.125 0.139 0.248 PB L2
ENSG00000162434 JAK1 629194 sc-eQTL 2.23e-01 0.0815 0.0667 0.263 Pro_T L2
ENSG00000162437 RAVER2 951853 sc-eQTL 7.98e-01 -0.0227 0.0884 0.263 Pro_T L2
ENSG00000184588 PDE4B -95566 sc-eQTL 9.58e-01 0.00438 0.0822 0.263 Pro_T L2
ENSG00000213625 LEPROT 276361 sc-eQTL 8.82e-01 -0.0155 0.104 0.263 Pro_T L2
ENSG00000162434 JAK1 629194 sc-eQTL 2.97e-01 0.0877 0.084 0.263 Treg L2
ENSG00000184588 PDE4B -95566 sc-eQTL 7.55e-01 -0.024 0.0768 0.263 Treg L2
ENSG00000213625 LEPROT 276361 sc-eQTL 5.98e-01 0.0576 0.109 0.263 Treg L2
ENSG00000116678 LEPR 276296 sc-eQTL 5.93e-01 0.057 0.107 0.256 cDC L2
ENSG00000162433 AK4 549399 sc-eQTL 3.45e-01 0.089 0.094 0.256 cDC L2
ENSG00000162434 JAK1 629194 sc-eQTL 6.41e-01 -0.0411 0.0879 0.256 cDC L2
ENSG00000162437 RAVER2 951853 sc-eQTL 8.32e-01 -0.0206 0.0966 0.256 cDC L2
ENSG00000184588 PDE4B -95566 sc-eQTL 7.45e-01 -0.0192 0.059 0.256 cDC L2
ENSG00000213625 LEPROT 276361 sc-eQTL 9.71e-01 0.00391 0.107 0.256 cDC L2
ENSG00000285079 AL513493.1 -7014 sc-eQTL 8.05e-01 -0.00951 0.0385 0.256 cDC L2
ENSG00000116678 LEPR 276296 sc-eQTL 2.20e-01 -0.125 0.102 0.263 cMono_IL1B L2
ENSG00000162433 AK4 549399 sc-eQTL 2.84e-01 -0.101 0.0936 0.263 cMono_IL1B L2
ENSG00000162434 JAK1 629194 sc-eQTL 8.45e-01 -0.0167 0.0853 0.263 cMono_IL1B L2
ENSG00000184588 PDE4B -95566 sc-eQTL 9.00e-01 -0.00598 0.0473 0.263 cMono_IL1B L2
ENSG00000213625 LEPROT 276361 sc-eQTL 7.69e-01 0.0203 0.0689 0.263 cMono_IL1B L2
ENSG00000116678 LEPR 276296 sc-eQTL 8.68e-01 0.0166 0.1 0.263 cMono_S100A L2
ENSG00000162433 AK4 549399 sc-eQTL 9.61e-01 -0.00464 0.0951 0.263 cMono_S100A L2
ENSG00000162434 JAK1 629194 sc-eQTL 6.57e-01 -0.039 0.0877 0.263 cMono_S100A L2
ENSG00000184588 PDE4B -95566 sc-eQTL 5.82e-01 -0.0273 0.0496 0.263 cMono_S100A L2
ENSG00000213625 LEPROT 276361 sc-eQTL 6.32e-02 -0.152 0.0814 0.263 cMono_S100A L2
ENSG00000162434 JAK1 629194 sc-eQTL 8.22e-01 0.0288 0.128 0.255 gdT L2
ENSG00000162437 RAVER2 951853 sc-eQTL 5.37e-01 -0.0694 0.112 0.255 gdT L2
ENSG00000184588 PDE4B -95566 sc-eQTL 3.51e-01 -0.0694 0.0741 0.255 gdT L2
ENSG00000213625 LEPROT 276361 sc-eQTL 6.50e-01 -0.0611 0.135 0.255 gdT L2
ENSG00000116678 LEPR 276296 sc-eQTL 8.94e-01 -0.0136 0.101 0.256 intMono L2
ENSG00000162433 AK4 549399 sc-eQTL 7.38e-01 0.0319 0.0954 0.256 intMono L2
ENSG00000162434 JAK1 629194 sc-eQTL 4.65e-02 0.175 0.0873 0.256 intMono L2
ENSG00000184588 PDE4B -95566 sc-eQTL 6.91e-01 -0.0203 0.0509 0.256 intMono L2
ENSG00000213625 LEPROT 276361 sc-eQTL 3.55e-01 -0.0786 0.0848 0.256 intMono L2
ENSG00000116678 LEPR 276296 sc-eQTL 5.87e-01 -0.0543 0.0998 0.251 ncMono L2
ENSG00000162433 AK4 549399 sc-eQTL 2.71e-02 0.196 0.088 0.251 ncMono L2
ENSG00000162434 JAK1 629194 sc-eQTL 4.99e-02 -0.141 0.0713 0.251 ncMono L2
ENSG00000184588 PDE4B -95566 sc-eQTL 6.35e-01 -0.0272 0.0572 0.251 ncMono L2
ENSG00000213625 LEPROT 276361 sc-eQTL 2.68e-01 -0.113 0.102 0.251 ncMono L2
ENSG00000116678 LEPR 276296 sc-eQTL 1.70e-01 0.141 0.102 0.263 pDC L2
ENSG00000162433 AK4 549399 sc-eQTL 8.33e-01 -0.0142 0.0671 0.263 pDC L2
ENSG00000162434 JAK1 629194 sc-eQTL 6.47e-01 -0.0411 0.0895 0.263 pDC L2
ENSG00000162437 RAVER2 951853 sc-eQTL 9.48e-01 0.00654 0.101 0.263 pDC L2
ENSG00000184588 PDE4B -95566 sc-eQTL 5.32e-01 -0.0489 0.0781 0.263 pDC L2
ENSG00000213625 LEPROT 276361 sc-eQTL 1.68e-01 -0.153 0.11 0.263 pDC L2
ENSG00000285079 AL513493.1 -7014 sc-eQTL 3.87e-04 0.292 0.0806 0.263 pDC L2
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 629194 sc-eQTL 7.81e-01 -0.0217 0.0782 0.263 B_Memory LOneK1K
ENSG00000184588 PDE4B -95566 sc-eQTL 6.78e-02 -0.117 0.0637 0.263 B_Memory LOneK1K
ENSG00000213625 LEPROT 276361 sc-eQTL 8.66e-01 -0.0169 0.1 0.263 B_Memory LOneK1K
ENSG00000162434 JAK1 629194 sc-eQTL 6.09e-01 -0.0386 0.0754 0.263 B_Naive LOneK1K
ENSG00000184588 PDE4B -95566 sc-eQTL 1.37e-02 -0.166 0.0668 0.263 B_Naive LOneK1K
ENSG00000213625 LEPROT 276361 sc-eQTL 5.97e-01 -0.0505 0.0953 0.263 B_Naive LOneK1K
ENSG00000116678 LEPR 276296 sc-eQTL 3.56e-01 -0.0923 0.0997 0.263 CD14_Mono LOneK1K
ENSG00000162433 AK4 549399 sc-eQTL 6.97e-01 -0.0372 0.0956 0.263 CD14_Mono LOneK1K
ENSG00000162434 JAK1 629194 sc-eQTL 9.17e-01 0.00833 0.08 0.263 CD14_Mono LOneK1K
ENSG00000184588 PDE4B -95566 sc-eQTL 5.67e-01 -0.0234 0.0408 0.263 CD14_Mono LOneK1K
ENSG00000213625 LEPROT 276361 sc-eQTL 7.36e-01 -0.0227 0.0671 0.263 CD14_Mono LOneK1K
ENSG00000116678 LEPR 276296 sc-eQTL 4.92e-01 -0.0697 0.101 0.261 CD16_Mono LOneK1K
ENSG00000162433 AK4 549399 sc-eQTL 6.39e-01 0.0431 0.0917 0.261 CD16_Mono LOneK1K
ENSG00000162434 JAK1 629194 sc-eQTL 9.65e-01 0.00272 0.0618 0.261 CD16_Mono LOneK1K
ENSG00000184588 PDE4B -95566 sc-eQTL 6.40e-01 -0.0221 0.0472 0.261 CD16_Mono LOneK1K
ENSG00000213625 LEPROT 276361 sc-eQTL 3.88e-02 -0.177 0.0852 0.261 CD16_Mono LOneK1K
ENSG00000116678 LEPR 276296 sc-eQTL 7.32e-01 0.0351 0.102 0.259 NK_CD56dim LOneK1K
ENSG00000162434 JAK1 629194 sc-eQTL 3.13e-01 -0.0483 0.0478 0.259 NK_CD56dim LOneK1K
ENSG00000184588 PDE4B -95566 sc-eQTL 2.84e-02 -0.162 0.0734 0.259 NK_CD56dim LOneK1K
ENSG00000213625 LEPROT 276361 sc-eQTL 8.77e-01 0.0163 0.106 0.259 NK_CD56dim LOneK1K

Statistical fine-mapping results from Japan COVID-19 Task Force
(Shown only for PIP>0.001)
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
PIP (SuSiE)
PIP (FINEMAP)
MAF
ENSG00000116675 DNAJC6 448729 eQTL 0.0247 0.0733 0.0326 0.00124 0.0 0.296
ENSG00000116678 LEPR 276296 eQTL 0.187 0.0325 0.0246 0.0153 0.0105 0.296

Expression Modifier Score(EMS) for GTEx 49tissues
Gene ID
Gene Symbol
TSS Distance
Whole Blood
Muscle Skeletal
Liver
Brain Cerebellum
Prostate
Spleen
Skin Sun Exposed Lower leg
Artery Coronary
Esophagus Muscularis
Esophagus Gastroesophageal Junction
Artery Tibial
Heart Atrial Appendage
Nerve Tibial
Heart Left Ventricle
Adrenal Gland
Adipose Visceral Omentum
Pancreas
Lung
Pituitary
Brain Nucleus accumbens basal ganglia
Colon Transverse
Adipose Subcutaneous
Esophagus Mucosa
Brain Cortex
Thyroid
Stomach
Breast Mammary Tissue
Colon Sigmoid
Skin Not Sun Exposed Suprapubic
Testis
Artery Aorta
Brain Amygdala
Brain Anterior cingulate cortex BA24
Brain Caudate basal ganglia
Brain Cerebellar Hemisphere
Brain Frontal Cortex BA9
Brain Hippocampus
Brain Hypothalamus
Brain Putamen basal ganglia
Brain Spinal cord cervical c-1
Brain Substantia nigra
Cells Cultured fibroblasts
Cells EBV-transformed lymphocytes
Kidney Cortex
Minor Salivary Gland
Ovary
Small Intestine Terminal Ileum
Uterus
Vagina
ENSG00000116675 DNAJC6 448729 7.3e-07 4.24e-07 8.67e-08 4.26e-07 1.07e-07 2.24e-07 4.53e-07 6.2e-08 2.66e-07 1.46e-07 4.13e-07 1.72e-07 7.02e-07 9.18e-08 1.24e-07 1.17e-07 1.01e-07 2.56e-07 8.68e-08 8e-08 1.48e-07 2.3e-07 2.11e-07 4.17e-08 5.53e-07 2.2e-07 2.24e-07 1.69e-07 1.47e-07 2.26e-07 1.86e-07 8.48e-08 4.97e-08 1.21e-07 3.34e-07 4.95e-08 1e-07 5.36e-08 4.99e-08 3.09e-08 5.39e-08 4.16e-07 2.67e-08 1.3e-07 3.71e-08 1.95e-08 9.68e-08 0.0 5.01e-08