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Genes within 1Mb (chr1:65689724:C:A):

View on , UCSC , GTEx , gnomAD

Immune cell-type specific single cell cis-eQTLs in OASIS
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 621970 sc-eQTL 2.29e-01 0.0752 0.0623 0.739 B L1
ENSG00000184588 PDE4B -102790 sc-eQTL 3.92e-02 0.134 0.0646 0.739 B L1
ENSG00000213625 LEPROT 269137 sc-eQTL 6.02e-01 0.0416 0.0798 0.739 B L1
ENSG00000162434 JAK1 621970 sc-eQTL 1.16e-01 0.0952 0.0604 0.739 CD4T L1
ENSG00000184588 PDE4B -102790 sc-eQTL 6.34e-01 0.0346 0.0724 0.739 CD4T L1
ENSG00000213625 LEPROT 269137 sc-eQTL 8.06e-02 0.166 0.0943 0.739 CD4T L1
ENSG00000116678 LEPR 269072 sc-eQTL 4.22e-02 0.208 0.102 0.739 CD8T L1
ENSG00000162434 JAK1 621970 sc-eQTL 4.83e-01 0.0559 0.0795 0.739 CD8T L1
ENSG00000184588 PDE4B -102790 sc-eQTL 1.03e-01 0.111 0.0675 0.739 CD8T L1
ENSG00000213625 LEPROT 269137 sc-eQTL 5.77e-01 0.0588 0.105 0.739 CD8T L1
ENSG00000116678 LEPR 269072 sc-eQTL 4.01e-01 -0.091 0.108 0.736 DC L1
ENSG00000162433 AK4 542175 sc-eQTL 1.64e-01 -0.127 0.0906 0.736 DC L1
ENSG00000162434 JAK1 621970 sc-eQTL 5.66e-01 0.0435 0.0756 0.736 DC L1
ENSG00000162437 RAVER2 944629 sc-eQTL 9.23e-01 -0.00933 0.097 0.736 DC L1
ENSG00000184588 PDE4B -102790 sc-eQTL 3.04e-01 0.0603 0.0585 0.736 DC L1
ENSG00000213625 LEPROT 269137 sc-eQTL 6.83e-01 -0.0439 0.107 0.736 DC L1
ENSG00000285079 AL513493.1 -14238 sc-eQTL 3.30e-04 -0.204 0.056 0.736 DC L1
ENSG00000116678 LEPR 269072 sc-eQTL 4.18e-01 0.0839 0.103 0.739 Mono L1
ENSG00000162433 AK4 542175 sc-eQTL 9.75e-01 0.00296 0.0948 0.739 Mono L1
ENSG00000162434 JAK1 621970 sc-eQTL 9.98e-01 0.000183 0.0676 0.739 Mono L1
ENSG00000184588 PDE4B -102790 sc-eQTL 8.71e-01 0.0061 0.0374 0.739 Mono L1
ENSG00000213625 LEPROT 269137 sc-eQTL 3.13e-01 0.0676 0.0668 0.739 Mono L1
ENSG00000116678 LEPR 269072 sc-eQTL 3.44e-01 -0.0955 0.101 0.74 NK L1
ENSG00000162434 JAK1 621970 sc-eQTL 2.75e-01 0.052 0.0475 0.74 NK L1
ENSG00000184588 PDE4B -102790 sc-eQTL 2.94e-03 0.192 0.0637 0.74 NK L1
ENSG00000213625 LEPROT 269137 sc-eQTL 9.31e-01 0.0094 0.109 0.74 NK L1
ENSG00000162434 JAK1 621970 sc-eQTL 2.22e-01 -0.0831 0.0679 0.739 Other_T L1
ENSG00000162437 RAVER2 944629 sc-eQTL 5.98e-01 -0.0523 0.099 0.739 Other_T L1
ENSG00000184588 PDE4B -102790 sc-eQTL 1.76e-01 0.1 0.0737 0.739 Other_T L1
ENSG00000213625 LEPROT 269137 sc-eQTL 6.64e-01 0.0466 0.107 0.739 Other_T L1
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 621970 sc-eQTL 4.86e-01 -0.0788 0.113 0.763 B_Activated L2
ENSG00000184588 PDE4B -102790 sc-eQTL 1.40e-02 0.219 0.0882 0.763 B_Activated L2
ENSG00000213625 LEPROT 269137 sc-eQTL 1.87e-01 0.156 0.118 0.763 B_Activated L2
ENSG00000162434 JAK1 621970 sc-eQTL 8.02e-01 0.0223 0.0889 0.74 B_Intermediate L2
ENSG00000184588 PDE4B -102790 sc-eQTL 1.86e-01 0.0958 0.0722 0.74 B_Intermediate L2
ENSG00000213625 LEPROT 269137 sc-eQTL 8.64e-01 -0.0178 0.104 0.74 B_Intermediate L2
ENSG00000162434 JAK1 621970 sc-eQTL 8.58e-01 -0.0159 0.0884 0.737 B_Memory L2
ENSG00000184588 PDE4B -102790 sc-eQTL 1.22e-01 0.14 0.0898 0.737 B_Memory L2
ENSG00000213625 LEPROT 269137 sc-eQTL 6.71e-01 0.0438 0.103 0.737 B_Memory L2
ENSG00000162434 JAK1 621970 sc-eQTL 6.69e-01 0.0341 0.0797 0.739 B_Naive1 L2
ENSG00000184588 PDE4B -102790 sc-eQTL 1.50e-02 0.186 0.0758 0.739 B_Naive1 L2
ENSG00000213625 LEPROT 269137 sc-eQTL 6.40e-01 0.0487 0.104 0.739 B_Naive1 L2
ENSG00000162434 JAK1 621970 sc-eQTL 4.42e-01 0.0641 0.0833 0.738 B_Naive2 L2
ENSG00000184588 PDE4B -102790 sc-eQTL 3.18e-02 0.141 0.0652 0.738 B_Naive2 L2
ENSG00000213625 LEPROT 269137 sc-eQTL 9.04e-01 -0.0121 0.101 0.738 B_Naive2 L2
ENSG00000162434 JAK1 621970 sc-eQTL 2.14e-01 0.12 0.0965 0.739 CD4_CTL L2
ENSG00000184588 PDE4B -102790 sc-eQTL 2.33e-02 0.194 0.0846 0.739 CD4_CTL L2
ENSG00000213625 LEPROT 269137 sc-eQTL 3.98e-01 0.0941 0.111 0.739 CD4_CTL L2
ENSG00000162434 JAK1 621970 sc-eQTL 1.45e-01 0.0866 0.0593 0.739 CD4_Naive L2
ENSG00000184588 PDE4B -102790 sc-eQTL 9.10e-01 0.00846 0.0745 0.739 CD4_Naive L2
ENSG00000213625 LEPROT 269137 sc-eQTL 2.47e-01 0.112 0.0963 0.739 CD4_Naive L2
ENSG00000162434 JAK1 621970 sc-eQTL 3.49e-01 0.0635 0.0676 0.739 CD4_TCM L2
ENSG00000184588 PDE4B -102790 sc-eQTL 5.20e-02 0.15 0.0769 0.739 CD4_TCM L2
ENSG00000213625 LEPROT 269137 sc-eQTL 8.88e-02 0.167 0.0976 0.739 CD4_TCM L2
ENSG00000162434 JAK1 621970 sc-eQTL 7.06e-01 -0.0345 0.0913 0.739 CD4_TEM L2
ENSG00000184588 PDE4B -102790 sc-eQTL 3.69e-01 0.0758 0.0842 0.739 CD4_TEM L2
ENSG00000213625 LEPROT 269137 sc-eQTL 1.68e-01 0.149 0.108 0.739 CD4_TEM L2
ENSG00000116678 LEPR 269072 sc-eQTL 1.43e-01 0.147 0.1 0.739 CD8_CTL L2
ENSG00000162434 JAK1 621970 sc-eQTL 9.08e-01 0.00974 0.0845 0.739 CD8_CTL L2
ENSG00000184588 PDE4B -102790 sc-eQTL 5.77e-03 0.214 0.0768 0.739 CD8_CTL L2
ENSG00000213625 LEPROT 269137 sc-eQTL 7.55e-02 0.183 0.102 0.739 CD8_CTL L2
ENSG00000116678 LEPR 269072 sc-eQTL 5.02e-01 0.0682 0.101 0.739 CD8_Naive L2
ENSG00000162434 JAK1 621970 sc-eQTL 3.03e-01 0.0872 0.0845 0.739 CD8_Naive L2
ENSG00000184588 PDE4B -102790 sc-eQTL 4.06e-01 0.0592 0.0711 0.739 CD8_Naive L2
ENSG00000213625 LEPROT 269137 sc-eQTL 2.99e-01 -0.108 0.103 0.739 CD8_Naive L2
ENSG00000116678 LEPR 269072 sc-eQTL 6.16e-01 0.0519 0.103 0.741 CD8_TCM L2
ENSG00000162434 JAK1 621970 sc-eQTL 7.98e-01 0.023 0.0898 0.741 CD8_TCM L2
ENSG00000184588 PDE4B -102790 sc-eQTL 7.83e-01 0.0272 0.0988 0.741 CD8_TCM L2
ENSG00000213625 LEPROT 269137 sc-eQTL 9.13e-01 0.0123 0.112 0.741 CD8_TCM L2
ENSG00000116678 LEPR 269072 sc-eQTL 7.61e-01 0.0286 0.0938 0.74 CD8_TEM L2
ENSG00000162434 JAK1 621970 sc-eQTL 1.93e-02 0.247 0.105 0.74 CD8_TEM L2
ENSG00000184588 PDE4B -102790 sc-eQTL 6.22e-02 0.168 0.0894 0.74 CD8_TEM L2
ENSG00000213625 LEPROT 269137 sc-eQTL 5.76e-01 -0.0613 0.109 0.74 CD8_TEM L2
ENSG00000162434 JAK1 621970 sc-eQTL 6.34e-01 -0.0437 0.0916 0.74 MAIT L2
ENSG00000162437 RAVER2 944629 sc-eQTL 5.29e-01 -0.0615 0.0975 0.74 MAIT L2
ENSG00000184588 PDE4B -102790 sc-eQTL 5.63e-02 0.149 0.0777 0.74 MAIT L2
ENSG00000213625 LEPROT 269137 sc-eQTL 6.46e-01 0.0486 0.105 0.74 MAIT L2
ENSG00000116678 LEPR 269072 sc-eQTL 3.76e-02 -0.204 0.0973 0.74 NK_CD56bright L2
ENSG00000162434 JAK1 621970 sc-eQTL 6.16e-01 -0.0339 0.0673 0.74 NK_CD56bright L2
ENSG00000184588 PDE4B -102790 sc-eQTL 5.30e-03 0.224 0.0793 0.74 NK_CD56bright L2
ENSG00000213625 LEPROT 269137 sc-eQTL 8.32e-01 -0.0235 0.111 0.74 NK_CD56bright L2
ENSG00000116678 LEPR 269072 sc-eQTL 5.12e-01 -0.0703 0.107 0.744 NK_CD56dim L2
ENSG00000162434 JAK1 621970 sc-eQTL 1.46e-01 0.0813 0.0557 0.744 NK_CD56dim L2
ENSG00000184588 PDE4B -102790 sc-eQTL 3.27e-01 0.0802 0.0817 0.744 NK_CD56dim L2
ENSG00000213625 LEPROT 269137 sc-eQTL 5.53e-01 0.0672 0.113 0.744 NK_CD56dim L2
ENSG00000116678 LEPR 269072 sc-eQTL 1.78e-01 0.127 0.0936 0.747 NK_HLA L2
ENSG00000162434 JAK1 621970 sc-eQTL 7.80e-02 -0.129 0.0726 0.747 NK_HLA L2
ENSG00000184588 PDE4B -102790 sc-eQTL 9.03e-02 0.151 0.0885 0.747 NK_HLA L2
ENSG00000213625 LEPROT 269137 sc-eQTL 5.89e-01 0.0614 0.113 0.747 NK_HLA L2
ENSG00000116678 LEPR 269072 sc-eQTL 6.58e-01 -0.0456 0.103 0.744 NK_cytokine L2
ENSG00000162434 JAK1 621970 sc-eQTL 7.55e-01 0.0187 0.0599 0.744 NK_cytokine L2
ENSG00000184588 PDE4B -102790 sc-eQTL 1.16e-02 0.236 0.0926 0.744 NK_cytokine L2
ENSG00000213625 LEPROT 269137 sc-eQTL 1.56e-01 -0.155 0.109 0.744 NK_cytokine L2
ENSG00000162434 JAK1 621970 sc-eQTL 6.04e-01 0.0538 0.103 0.756 PB L2
ENSG00000184588 PDE4B -102790 sc-eQTL 6.98e-01 -0.0511 0.131 0.756 PB L2
ENSG00000213625 LEPROT 269137 sc-eQTL 4.94e-01 -0.0992 0.145 0.756 PB L2
ENSG00000162434 JAK1 621970 sc-eQTL 1.91e-01 -0.089 0.0678 0.739 Pro_T L2
ENSG00000162437 RAVER2 944629 sc-eQTL 8.78e-01 0.0139 0.0898 0.739 Pro_T L2
ENSG00000184588 PDE4B -102790 sc-eQTL 9.01e-01 -0.0104 0.0836 0.739 Pro_T L2
ENSG00000213625 LEPROT 269137 sc-eQTL 6.57e-01 0.0471 0.106 0.739 Pro_T L2
ENSG00000162434 JAK1 621970 sc-eQTL 2.59e-01 -0.0966 0.0854 0.739 Treg L2
ENSG00000184588 PDE4B -102790 sc-eQTL 6.37e-01 0.037 0.0781 0.739 Treg L2
ENSG00000213625 LEPROT 269137 sc-eQTL 6.98e-01 -0.0431 0.111 0.739 Treg L2
ENSG00000116678 LEPR 269072 sc-eQTL 5.30e-01 -0.069 0.11 0.746 cDC L2
ENSG00000162433 AK4 542175 sc-eQTL 3.71e-01 -0.0868 0.0967 0.746 cDC L2
ENSG00000162434 JAK1 621970 sc-eQTL 5.67e-01 0.0518 0.0904 0.746 cDC L2
ENSG00000162437 RAVER2 944629 sc-eQTL 9.48e-01 -0.00653 0.0994 0.746 cDC L2
ENSG00000184588 PDE4B -102790 sc-eQTL 5.50e-01 0.0363 0.0607 0.746 cDC L2
ENSG00000213625 LEPROT 269137 sc-eQTL 8.92e-01 -0.0149 0.11 0.746 cDC L2
ENSG00000285079 AL513493.1 -14238 sc-eQTL 7.73e-01 0.0114 0.0396 0.746 cDC L2
ENSG00000116678 LEPR 269072 sc-eQTL 1.92e-01 0.136 0.104 0.739 cMono_IL1B L2
ENSG00000162433 AK4 542175 sc-eQTL 3.40e-01 0.0918 0.096 0.739 cMono_IL1B L2
ENSG00000162434 JAK1 621970 sc-eQTL 8.68e-01 0.0145 0.0875 0.739 cMono_IL1B L2
ENSG00000184588 PDE4B -102790 sc-eQTL 8.85e-01 0.00704 0.0485 0.739 cMono_IL1B L2
ENSG00000213625 LEPROT 269137 sc-eQTL 8.38e-01 -0.0144 0.0707 0.739 cMono_IL1B L2
ENSG00000116678 LEPR 269072 sc-eQTL 7.86e-01 -0.0277 0.102 0.739 cMono_S100A L2
ENSG00000162433 AK4 542175 sc-eQTL 7.58e-01 0.0299 0.097 0.739 cMono_S100A L2
ENSG00000162434 JAK1 621970 sc-eQTL 7.47e-01 0.0289 0.0895 0.739 cMono_S100A L2
ENSG00000184588 PDE4B -102790 sc-eQTL 5.31e-01 0.0318 0.0506 0.739 cMono_S100A L2
ENSG00000213625 LEPROT 269137 sc-eQTL 4.07e-02 0.171 0.0829 0.739 cMono_S100A L2
ENSG00000162434 JAK1 621970 sc-eQTL 9.29e-01 -0.0114 0.128 0.742 gdT L2
ENSG00000162437 RAVER2 944629 sc-eQTL 5.22e-01 0.0721 0.112 0.742 gdT L2
ENSG00000184588 PDE4B -102790 sc-eQTL 3.10e-01 0.0756 0.0742 0.742 gdT L2
ENSG00000213625 LEPROT 269137 sc-eQTL 5.22e-01 0.0863 0.135 0.742 gdT L2
ENSG00000116678 LEPR 269072 sc-eQTL 7.74e-01 0.0298 0.104 0.747 intMono L2
ENSG00000162433 AK4 542175 sc-eQTL 7.30e-01 -0.0338 0.0976 0.747 intMono L2
ENSG00000162434 JAK1 621970 sc-eQTL 4.10e-02 -0.184 0.0894 0.747 intMono L2
ENSG00000184588 PDE4B -102790 sc-eQTL 5.55e-01 0.0308 0.0521 0.747 intMono L2
ENSG00000213625 LEPROT 269137 sc-eQTL 4.72e-01 0.0626 0.087 0.747 intMono L2
ENSG00000116678 LEPR 269072 sc-eQTL 7.30e-01 0.0353 0.102 0.751 ncMono L2
ENSG00000162433 AK4 542175 sc-eQTL 2.71e-02 -0.2 0.0899 0.751 ncMono L2
ENSG00000162434 JAK1 621970 sc-eQTL 4.79e-02 0.145 0.0729 0.751 ncMono L2
ENSG00000184588 PDE4B -102790 sc-eQTL 7.63e-01 0.0177 0.0585 0.751 ncMono L2
ENSG00000213625 LEPROT 269137 sc-eQTL 3.64e-01 0.0949 0.104 0.751 ncMono L2
ENSG00000116678 LEPR 269072 sc-eQTL 1.58e-01 -0.148 0.104 0.74 pDC L2
ENSG00000162433 AK4 542175 sc-eQTL 8.06e-01 0.0168 0.0685 0.74 pDC L2
ENSG00000162434 JAK1 621970 sc-eQTL 8.23e-01 0.0205 0.0915 0.74 pDC L2
ENSG00000162437 RAVER2 944629 sc-eQTL 8.06e-01 0.0253 0.103 0.74 pDC L2
ENSG00000184588 PDE4B -102790 sc-eQTL 7.60e-01 0.0245 0.0798 0.74 pDC L2
ENSG00000213625 LEPROT 269137 sc-eQTL 1.91e-01 0.148 0.113 0.74 pDC L2
ENSG00000285079 AL513493.1 -14238 sc-eQTL 6.92e-04 -0.286 0.0825 0.74 pDC L2
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 621970 sc-eQTL 5.75e-01 0.0444 0.0791 0.739 B_Memory LOneK1K
ENSG00000184588 PDE4B -102790 sc-eQTL 5.99e-02 0.122 0.0644 0.739 B_Memory LOneK1K
ENSG00000213625 LEPROT 269137 sc-eQTL 6.93e-01 0.0402 0.102 0.739 B_Memory LOneK1K
ENSG00000162434 JAK1 621970 sc-eQTL 4.19e-01 0.0623 0.0769 0.739 B_Naive LOneK1K
ENSG00000184588 PDE4B -102790 sc-eQTL 7.04e-03 0.185 0.068 0.739 B_Naive LOneK1K
ENSG00000213625 LEPROT 269137 sc-eQTL 5.45e-01 0.059 0.0973 0.739 B_Naive LOneK1K
ENSG00000116678 LEPR 269072 sc-eQTL 3.52e-01 0.0953 0.102 0.739 CD14_Mono LOneK1K
ENSG00000162433 AK4 542175 sc-eQTL 6.12e-01 0.0497 0.0979 0.739 CD14_Mono LOneK1K
ENSG00000162434 JAK1 621970 sc-eQTL 9.06e-01 -0.00973 0.082 0.739 CD14_Mono LOneK1K
ENSG00000184588 PDE4B -102790 sc-eQTL 5.60e-01 0.0244 0.0418 0.739 CD14_Mono LOneK1K
ENSG00000213625 LEPROT 269137 sc-eQTL 6.13e-01 0.0348 0.0687 0.739 CD14_Mono LOneK1K
ENSG00000116678 LEPR 269072 sc-eQTL 5.38e-01 0.064 0.104 0.741 CD16_Mono LOneK1K
ENSG00000162433 AK4 542175 sc-eQTL 6.69e-01 -0.0402 0.094 0.741 CD16_Mono LOneK1K
ENSG00000162434 JAK1 621970 sc-eQTL 9.70e-01 -0.00242 0.0633 0.741 CD16_Mono LOneK1K
ENSG00000184588 PDE4B -102790 sc-eQTL 6.88e-01 0.0194 0.0483 0.741 CD16_Mono LOneK1K
ENSG00000213625 LEPROT 269137 sc-eQTL 6.87e-02 0.16 0.0875 0.741 CD16_Mono LOneK1K
ENSG00000116678 LEPR 269072 sc-eQTL 5.06e-01 -0.0693 0.104 0.744 NK_CD56dim LOneK1K
ENSG00000162434 JAK1 621970 sc-eQTL 2.44e-01 0.0569 0.0487 0.744 NK_CD56dim LOneK1K
ENSG00000184588 PDE4B -102790 sc-eQTL 4.00e-02 0.155 0.075 0.744 NK_CD56dim LOneK1K
ENSG00000213625 LEPROT 269137 sc-eQTL 8.42e-01 -0.0216 0.108 0.744 NK_CD56dim LOneK1K

Statistical fine-mapping results from Japan COVID-19 Task Force
(Shown only for PIP>0.001)
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
PIP (SuSiE)
PIP (FINEMAP)
MAF
ENSG00000116675 DNAJC6 441505 eQTL 0.024 -0.0741 0.0328 0.00126 0.0 0.294
ENSG00000116678 LEPR 269072 eQTL 0.209 -0.0311 0.0248 0.0122 0.00838 0.294
ENSG00000213625 LEPROT 269137 eQTL 0.0377 0.0431 0.0207 0.0 0.0 0.294

Expression Modifier Score(EMS) for GTEx 49tissues
Gene ID
Gene Symbol
TSS Distance
Whole Blood
Muscle Skeletal
Liver
Brain Cerebellum
Prostate
Spleen
Skin Sun Exposed Lower leg
Artery Coronary
Esophagus Muscularis
Esophagus Gastroesophageal Junction
Artery Tibial
Heart Atrial Appendage
Nerve Tibial
Heart Left Ventricle
Adrenal Gland
Adipose Visceral Omentum
Pancreas
Lung
Pituitary
Brain Nucleus accumbens basal ganglia
Colon Transverse
Adipose Subcutaneous
Esophagus Mucosa
Brain Cortex
Thyroid
Stomach
Breast Mammary Tissue
Colon Sigmoid
Skin Not Sun Exposed Suprapubic
Testis
Artery Aorta
Brain Amygdala
Brain Anterior cingulate cortex BA24
Brain Caudate basal ganglia
Brain Cerebellar Hemisphere
Brain Frontal Cortex BA9
Brain Hippocampus
Brain Hypothalamus
Brain Putamen basal ganglia
Brain Spinal cord cervical c-1
Brain Substantia nigra
Cells Cultured fibroblasts
Cells EBV-transformed lymphocytes
Kidney Cortex
Minor Salivary Gland
Ovary
Small Intestine Terminal Ileum
Uterus
Vagina
ENSG00000116675 DNAJC6 441505 5.59e-07 2.67e-07 7.76e-08 2.79e-07 1.07e-07 1.32e-07 3.7e-07 8.86e-08 2.38e-07 1.5e-07 3.32e-07 2.28e-07 4.34e-07 9.15e-08 9.12e-08 1.26e-07 1.18e-07 2.93e-07 9.69e-08 7.4e-08 1.57e-07 2.3e-07 2.48e-07 7.94e-08 3.7e-07 1.9e-07 1.74e-07 1.68e-07 2.03e-07 2.89e-07 1.88e-07 7.4e-08 5.75e-08 1.27e-07 1.69e-07 6.85e-08 7.52e-08 6.2e-08 5.7e-08 7.55e-08 3.46e-08 2.74e-07 1.96e-08 1.54e-08 8.45e-08 9.12e-09 9.38e-08 3.25e-09 5.61e-08