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Genes within 1Mb (chr1:65647977:C:CAT):

View on , UCSC , GTEx , gnomAD

Immune cell-type specific single cell cis-eQTLs in OASIS
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 580223 sc-eQTL 3.00e-01 0.0667 0.0643 0.754 B L1
ENSG00000184588 PDE4B -144537 sc-eQTL 1.22e-01 0.104 0.0669 0.754 B L1
ENSG00000213625 LEPROT 227390 sc-eQTL 4.36e-01 0.0642 0.0822 0.754 B L1
ENSG00000162434 JAK1 580223 sc-eQTL 3.31e-01 0.0607 0.0623 0.754 CD4T L1
ENSG00000184588 PDE4B -144537 sc-eQTL 2.26e-01 0.0901 0.0742 0.754 CD4T L1
ENSG00000213625 LEPROT 227390 sc-eQTL 7.31e-02 0.174 0.0969 0.754 CD4T L1
ENSG00000116678 LEPR 227325 sc-eQTL 5.49e-02 0.201 0.104 0.754 CD8T L1
ENSG00000162434 JAK1 580223 sc-eQTL 7.33e-01 0.0277 0.0813 0.754 CD8T L1
ENSG00000184588 PDE4B -144537 sc-eQTL 9.67e-02 0.115 0.069 0.754 CD8T L1
ENSG00000213625 LEPROT 227390 sc-eQTL 3.70e-01 0.0967 0.108 0.754 CD8T L1
ENSG00000116678 LEPR 227325 sc-eQTL 7.73e-01 -0.032 0.111 0.752 DC L1
ENSG00000162433 AK4 500428 sc-eQTL 3.07e-01 -0.0954 0.0931 0.752 DC L1
ENSG00000162434 JAK1 580223 sc-eQTL 6.56e-01 -0.0346 0.0776 0.752 DC L1
ENSG00000162437 RAVER2 902882 sc-eQTL 9.99e-01 -8.19e-05 0.0994 0.752 DC L1
ENSG00000184588 PDE4B -144537 sc-eQTL 2.35e-01 0.0713 0.0599 0.752 DC L1
ENSG00000213625 LEPROT 227390 sc-eQTL 9.17e-01 0.0114 0.11 0.752 DC L1
ENSG00000285079 AL513493.1 -55985 sc-eQTL 3.75e-04 -0.208 0.0574 0.752 DC L1
ENSG00000116678 LEPR 227325 sc-eQTL 3.27e-01 0.103 0.105 0.754 Mono L1
ENSG00000162433 AK4 500428 sc-eQTL 9.53e-01 0.00566 0.0959 0.754 Mono L1
ENSG00000162434 JAK1 580223 sc-eQTL 6.35e-01 -0.0325 0.0684 0.754 Mono L1
ENSG00000184588 PDE4B -144537 sc-eQTL 9.75e-01 0.00119 0.0379 0.754 Mono L1
ENSG00000213625 LEPROT 227390 sc-eQTL 5.78e-01 0.0377 0.0677 0.754 Mono L1
ENSG00000116678 LEPR 227325 sc-eQTL 5.77e-01 -0.0573 0.103 0.755 NK L1
ENSG00000162434 JAK1 580223 sc-eQTL 5.09e-01 0.032 0.0485 0.755 NK L1
ENSG00000184588 PDE4B -144537 sc-eQTL 1.49e-02 0.16 0.0653 0.755 NK L1
ENSG00000213625 LEPROT 227390 sc-eQTL 9.50e-01 0.00699 0.111 0.755 NK L1
ENSG00000162434 JAK1 580223 sc-eQTL 4.42e-01 -0.0537 0.0698 0.754 Other_T L1
ENSG00000162437 RAVER2 902882 sc-eQTL 3.24e-01 -0.1 0.101 0.754 Other_T L1
ENSG00000184588 PDE4B -144537 sc-eQTL 2.22e-01 0.0926 0.0756 0.754 Other_T L1
ENSG00000213625 LEPROT 227390 sc-eQTL 8.60e-01 -0.0194 0.11 0.754 Other_T L1
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 580223 sc-eQTL 6.46e-01 -0.0542 0.118 0.778 B_Activated L2
ENSG00000184588 PDE4B -144537 sc-eQTL 7.07e-02 0.169 0.0928 0.778 B_Activated L2
ENSG00000213625 LEPROT 227390 sc-eQTL 2.56e-01 0.14 0.123 0.778 B_Activated L2
ENSG00000162434 JAK1 580223 sc-eQTL 9.82e-01 0.00206 0.0915 0.755 B_Intermediate L2
ENSG00000184588 PDE4B -144537 sc-eQTL 6.39e-01 0.0349 0.0745 0.755 B_Intermediate L2
ENSG00000213625 LEPROT 227390 sc-eQTL 7.62e-01 0.0325 0.107 0.755 B_Intermediate L2
ENSG00000162434 JAK1 580223 sc-eQTL 5.91e-01 -0.0491 0.0913 0.752 B_Memory L2
ENSG00000184588 PDE4B -144537 sc-eQTL 2.28e-01 0.113 0.093 0.752 B_Memory L2
ENSG00000213625 LEPROT 227390 sc-eQTL 8.57e-01 0.0191 0.106 0.752 B_Memory L2
ENSG00000162434 JAK1 580223 sc-eQTL 8.64e-01 0.0141 0.0818 0.754 B_Naive1 L2
ENSG00000184588 PDE4B -144537 sc-eQTL 2.46e-02 0.176 0.0779 0.754 B_Naive1 L2
ENSG00000213625 LEPROT 227390 sc-eQTL 5.16e-01 0.0694 0.107 0.754 B_Naive1 L2
ENSG00000162434 JAK1 580223 sc-eQTL 5.97e-01 0.0453 0.0856 0.753 B_Naive2 L2
ENSG00000184588 PDE4B -144537 sc-eQTL 3.58e-02 0.142 0.067 0.753 B_Naive2 L2
ENSG00000213625 LEPROT 227390 sc-eQTL 7.21e-01 -0.0368 0.103 0.753 B_Naive2 L2
ENSG00000162434 JAK1 580223 sc-eQTL 8.09e-01 0.0241 0.0999 0.755 CD4_CTL L2
ENSG00000184588 PDE4B -144537 sc-eQTL 2.85e-02 0.193 0.0874 0.755 CD4_CTL L2
ENSG00000213625 LEPROT 227390 sc-eQTL 9.78e-01 -0.00311 0.115 0.755 CD4_CTL L2
ENSG00000162434 JAK1 580223 sc-eQTL 3.18e-01 0.061 0.061 0.754 CD4_Naive L2
ENSG00000184588 PDE4B -144537 sc-eQTL 4.92e-01 0.0526 0.0764 0.754 CD4_Naive L2
ENSG00000213625 LEPROT 227390 sc-eQTL 2.50e-01 0.114 0.0988 0.754 CD4_Naive L2
ENSG00000162434 JAK1 580223 sc-eQTL 5.43e-01 0.0423 0.0695 0.754 CD4_TCM L2
ENSG00000184588 PDE4B -144537 sc-eQTL 2.59e-02 0.177 0.0787 0.754 CD4_TCM L2
ENSG00000213625 LEPROT 227390 sc-eQTL 2.46e-02 0.226 0.0996 0.754 CD4_TCM L2
ENSG00000162434 JAK1 580223 sc-eQTL 5.67e-01 -0.0535 0.0933 0.754 CD4_TEM L2
ENSG00000184588 PDE4B -144537 sc-eQTL 2.03e-01 0.11 0.0859 0.754 CD4_TEM L2
ENSG00000213625 LEPROT 227390 sc-eQTL 1.58e-01 0.156 0.11 0.754 CD4_TEM L2
ENSG00000116678 LEPR 227325 sc-eQTL 1.07e-01 0.166 0.103 0.754 CD8_CTL L2
ENSG00000162434 JAK1 580223 sc-eQTL 9.97e-01 0.000325 0.0867 0.754 CD8_CTL L2
ENSG00000184588 PDE4B -144537 sc-eQTL 1.50e-02 0.194 0.0791 0.754 CD8_CTL L2
ENSG00000213625 LEPROT 227390 sc-eQTL 4.73e-02 0.209 0.105 0.754 CD8_CTL L2
ENSG00000116678 LEPR 227325 sc-eQTL 4.00e-01 0.0876 0.104 0.754 CD8_Naive L2
ENSG00000162434 JAK1 580223 sc-eQTL 7.27e-01 0.0303 0.0867 0.754 CD8_Naive L2
ENSG00000184588 PDE4B -144537 sc-eQTL 3.69e-01 0.0655 0.0728 0.754 CD8_Naive L2
ENSG00000213625 LEPROT 227390 sc-eQTL 4.46e-01 -0.081 0.106 0.754 CD8_Naive L2
ENSG00000116678 LEPR 227325 sc-eQTL 7.09e-01 0.0394 0.106 0.755 CD8_TCM L2
ENSG00000162434 JAK1 580223 sc-eQTL 9.29e-01 0.00814 0.0918 0.755 CD8_TCM L2
ENSG00000184588 PDE4B -144537 sc-eQTL 7.96e-01 0.0261 0.101 0.755 CD8_TCM L2
ENSG00000213625 LEPROT 227390 sc-eQTL 7.64e-01 0.0344 0.115 0.755 CD8_TCM L2
ENSG00000116678 LEPR 227325 sc-eQTL 9.60e-01 0.00483 0.0972 0.753 CD8_TEM L2
ENSG00000162434 JAK1 580223 sc-eQTL 1.44e-01 0.16 0.109 0.753 CD8_TEM L2
ENSG00000184588 PDE4B -144537 sc-eQTL 9.91e-02 0.154 0.0928 0.753 CD8_TEM L2
ENSG00000213625 LEPROT 227390 sc-eQTL 5.48e-01 -0.0681 0.113 0.753 CD8_TEM L2
ENSG00000162434 JAK1 580223 sc-eQTL 8.85e-01 -0.0136 0.0938 0.755 MAIT L2
ENSG00000162437 RAVER2 902882 sc-eQTL 6.46e-01 -0.046 0.0999 0.755 MAIT L2
ENSG00000184588 PDE4B -144537 sc-eQTL 1.17e-01 0.125 0.0797 0.755 MAIT L2
ENSG00000213625 LEPROT 227390 sc-eQTL 8.61e-01 -0.019 0.108 0.755 MAIT L2
ENSG00000116678 LEPR 227325 sc-eQTL 2.04e-02 -0.232 0.0992 0.756 NK_CD56bright L2
ENSG00000162434 JAK1 580223 sc-eQTL 5.42e-01 -0.042 0.0688 0.756 NK_CD56bright L2
ENSG00000184588 PDE4B -144537 sc-eQTL 7.12e-02 0.149 0.082 0.756 NK_CD56bright L2
ENSG00000213625 LEPROT 227390 sc-eQTL 7.41e-01 -0.0375 0.113 0.756 NK_CD56bright L2
ENSG00000116678 LEPR 227325 sc-eQTL 6.90e-01 -0.0435 0.109 0.759 NK_CD56dim L2
ENSG00000162434 JAK1 580223 sc-eQTL 2.38e-01 0.0671 0.0567 0.759 NK_CD56dim L2
ENSG00000184588 PDE4B -144537 sc-eQTL 3.69e-01 0.0746 0.0829 0.759 NK_CD56dim L2
ENSG00000213625 LEPROT 227390 sc-eQTL 3.09e-01 0.117 0.115 0.759 NK_CD56dim L2
ENSG00000116678 LEPR 227325 sc-eQTL 1.94e-01 0.124 0.0953 0.76 NK_HLA L2
ENSG00000162434 JAK1 580223 sc-eQTL 8.58e-02 -0.128 0.074 0.76 NK_HLA L2
ENSG00000184588 PDE4B -144537 sc-eQTL 5.70e-02 0.172 0.0899 0.76 NK_HLA L2
ENSG00000213625 LEPROT 227390 sc-eQTL 2.45e-01 0.134 0.115 0.76 NK_HLA L2
ENSG00000116678 LEPR 227325 sc-eQTL 8.10e-01 -0.0253 0.105 0.759 NK_cytokine L2
ENSG00000162434 JAK1 580223 sc-eQTL 9.05e-01 -0.00727 0.061 0.759 NK_cytokine L2
ENSG00000184588 PDE4B -144537 sc-eQTL 2.22e-02 0.218 0.0945 0.759 NK_cytokine L2
ENSG00000213625 LEPROT 227390 sc-eQTL 4.91e-02 -0.218 0.11 0.759 NK_cytokine L2
ENSG00000162434 JAK1 580223 sc-eQTL 7.42e-01 0.0336 0.102 0.767 PB L2
ENSG00000184588 PDE4B -144537 sc-eQTL 9.08e-01 0.015 0.129 0.767 PB L2
ENSG00000213625 LEPROT 227390 sc-eQTL 6.22e-01 -0.0705 0.142 0.767 PB L2
ENSG00000162434 JAK1 580223 sc-eQTL 3.49e-01 -0.0651 0.0694 0.754 Pro_T L2
ENSG00000162437 RAVER2 902882 sc-eQTL 8.61e-01 -0.0161 0.0918 0.754 Pro_T L2
ENSG00000184588 PDE4B -144537 sc-eQTL 7.66e-01 -0.0254 0.0854 0.754 Pro_T L2
ENSG00000213625 LEPROT 227390 sc-eQTL 4.28e-01 0.0858 0.108 0.754 Pro_T L2
ENSG00000162434 JAK1 580223 sc-eQTL 1.70e-01 -0.121 0.088 0.754 Treg L2
ENSG00000184588 PDE4B -144537 sc-eQTL 3.11e-01 0.0817 0.0804 0.754 Treg L2
ENSG00000213625 LEPROT 227390 sc-eQTL 8.39e-01 -0.0233 0.115 0.754 Treg L2
ENSG00000116678 LEPR 227325 sc-eQTL 6.44e-01 -0.0518 0.112 0.763 cDC L2
ENSG00000162433 AK4 500428 sc-eQTL 4.01e-01 -0.0832 0.0987 0.763 cDC L2
ENSG00000162434 JAK1 580223 sc-eQTL 7.74e-01 -0.0265 0.0923 0.763 cDC L2
ENSG00000162437 RAVER2 902882 sc-eQTL 9.98e-01 0.000302 0.101 0.763 cDC L2
ENSG00000184588 PDE4B -144537 sc-eQTL 8.89e-01 0.00866 0.062 0.763 cDC L2
ENSG00000213625 LEPROT 227390 sc-eQTL 6.70e-01 0.048 0.113 0.763 cDC L2
ENSG00000285079 AL513493.1 -55985 sc-eQTL 7.82e-01 0.0112 0.0404 0.763 cDC L2
ENSG00000116678 LEPR 227325 sc-eQTL 1.59e-01 0.15 0.106 0.754 cMono_IL1B L2
ENSG00000162433 AK4 500428 sc-eQTL 3.04e-01 0.101 0.0975 0.754 cMono_IL1B L2
ENSG00000162434 JAK1 580223 sc-eQTL 8.86e-01 -0.0128 0.0889 0.754 cMono_IL1B L2
ENSG00000184588 PDE4B -144537 sc-eQTL 8.01e-01 0.0125 0.0493 0.754 cMono_IL1B L2
ENSG00000213625 LEPROT 227390 sc-eQTL 6.74e-01 -0.0302 0.0718 0.754 cMono_IL1B L2
ENSG00000116678 LEPR 227325 sc-eQTL 5.52e-01 -0.0614 0.103 0.754 cMono_S100A L2
ENSG00000162433 AK4 500428 sc-eQTL 8.79e-01 0.0149 0.0978 0.754 cMono_S100A L2
ENSG00000162434 JAK1 580223 sc-eQTL 8.85e-01 0.013 0.0903 0.754 cMono_S100A L2
ENSG00000184588 PDE4B -144537 sc-eQTL 5.32e-01 0.032 0.051 0.754 cMono_S100A L2
ENSG00000213625 LEPROT 227390 sc-eQTL 1.58e-01 0.119 0.0841 0.754 cMono_S100A L2
ENSG00000162434 JAK1 580223 sc-eQTL 7.08e-01 0.0503 0.134 0.761 gdT L2
ENSG00000162437 RAVER2 902882 sc-eQTL 4.77e-01 0.0842 0.118 0.761 gdT L2
ENSG00000184588 PDE4B -144537 sc-eQTL 3.08e-01 0.0797 0.078 0.761 gdT L2
ENSG00000213625 LEPROT 227390 sc-eQTL 7.07e-01 0.0534 0.142 0.761 gdT L2
ENSG00000116678 LEPR 227325 sc-eQTL 3.19e-01 0.106 0.106 0.76 intMono L2
ENSG00000162433 AK4 500428 sc-eQTL 4.68e-01 -0.0726 0.0998 0.76 intMono L2
ENSG00000162434 JAK1 580223 sc-eQTL 2.58e-02 -0.205 0.0913 0.76 intMono L2
ENSG00000184588 PDE4B -144537 sc-eQTL 3.72e-01 0.0476 0.0533 0.76 intMono L2
ENSG00000213625 LEPROT 227390 sc-eQTL 9.68e-01 0.00363 0.089 0.76 intMono L2
ENSG00000116678 LEPR 227325 sc-eQTL 6.79e-01 0.043 0.104 0.762 ncMono L2
ENSG00000162433 AK4 500428 sc-eQTL 5.58e-02 -0.176 0.0917 0.762 ncMono L2
ENSG00000162434 JAK1 580223 sc-eQTL 1.62e-01 0.105 0.0745 0.762 ncMono L2
ENSG00000184588 PDE4B -144537 sc-eQTL 7.95e-01 0.0155 0.0595 0.762 ncMono L2
ENSG00000213625 LEPROT 227390 sc-eQTL 4.30e-01 0.0839 0.106 0.762 ncMono L2
ENSG00000116678 LEPR 227325 sc-eQTL 2.22e-01 -0.135 0.11 0.76 pDC L2
ENSG00000162433 AK4 500428 sc-eQTL 9.19e-01 -0.00739 0.0722 0.76 pDC L2
ENSG00000162434 JAK1 580223 sc-eQTL 9.97e-01 -0.00037 0.0965 0.76 pDC L2
ENSG00000162437 RAVER2 902882 sc-eQTL 7.21e-01 0.0389 0.109 0.76 pDC L2
ENSG00000184588 PDE4B -144537 sc-eQTL 4.28e-01 0.0668 0.084 0.76 pDC L2
ENSG00000213625 LEPROT 227390 sc-eQTL 5.45e-02 0.229 0.118 0.76 pDC L2
ENSG00000285079 AL513493.1 -55985 sc-eQTL 5.27e-04 -0.308 0.0869 0.76 pDC L2
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 580223 sc-eQTL 7.18e-01 0.0295 0.0816 0.754 B_Memory LOneK1K
ENSG00000184588 PDE4B -144537 sc-eQTL 2.74e-01 0.0734 0.0669 0.754 B_Memory LOneK1K
ENSG00000213625 LEPROT 227390 sc-eQTL 5.04e-01 0.07 0.105 0.754 B_Memory LOneK1K
ENSG00000162434 JAK1 580223 sc-eQTL 6.55e-01 0.0353 0.0789 0.754 B_Naive LOneK1K
ENSG00000184588 PDE4B -144537 sc-eQTL 1.61e-02 0.17 0.07 0.754 B_Naive LOneK1K
ENSG00000213625 LEPROT 227390 sc-eQTL 5.53e-01 0.0593 0.0998 0.754 B_Naive LOneK1K
ENSG00000116678 LEPR 227325 sc-eQTL 3.49e-01 0.097 0.103 0.754 CD14_Mono LOneK1K
ENSG00000162433 AK4 500428 sc-eQTL 6.77e-01 0.0414 0.0991 0.754 CD14_Mono LOneK1K
ENSG00000162434 JAK1 580223 sc-eQTL 7.57e-01 -0.0257 0.0829 0.754 CD14_Mono LOneK1K
ENSG00000184588 PDE4B -144537 sc-eQTL 5.93e-01 0.0226 0.0423 0.754 CD14_Mono LOneK1K
ENSG00000213625 LEPROT 227390 sc-eQTL 9.17e-01 0.00722 0.0695 0.754 CD14_Mono LOneK1K
ENSG00000116678 LEPR 227325 sc-eQTL 2.75e-01 0.116 0.106 0.756 CD16_Mono LOneK1K
ENSG00000162433 AK4 500428 sc-eQTL 6.20e-01 -0.0475 0.0958 0.756 CD16_Mono LOneK1K
ENSG00000162434 JAK1 580223 sc-eQTL 6.79e-01 -0.0267 0.0645 0.756 CD16_Mono LOneK1K
ENSG00000184588 PDE4B -144537 sc-eQTL 6.82e-01 0.0202 0.0493 0.756 CD16_Mono LOneK1K
ENSG00000213625 LEPROT 227390 sc-eQTL 1.72e-01 0.123 0.0895 0.756 CD16_Mono LOneK1K
ENSG00000116678 LEPR 227325 sc-eQTL 8.47e-01 -0.0205 0.106 0.759 NK_CD56dim LOneK1K
ENSG00000162434 JAK1 580223 sc-eQTL 4.08e-01 0.0412 0.0497 0.759 NK_CD56dim LOneK1K
ENSG00000184588 PDE4B -144537 sc-eQTL 4.29e-02 0.156 0.0765 0.759 NK_CD56dim LOneK1K
ENSG00000213625 LEPROT 227390 sc-eQTL 8.43e-01 -0.0218 0.11 0.759 NK_CD56dim LOneK1K

Statistical fine-mapping results from Japan COVID-19 Task Force
(Shown only for PIP>0.001)
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
PIP (SuSiE)
PIP (FINEMAP)
MAF
ENSG00000116675 DNAJC6 399758 eQTL 0.0289 -0.0731 0.0334 0.00116 0.0 0.281
ENSG00000116678 LEPR 227325 eQTL 0.361 -0.0231 0.0253 0.00757 0.00431 0.281
ENSG00000213625 LEPROT 227390 eQTL 0.00847 0.0556 0.0211 0.0 0.0 0.281

Expression Modifier Score(EMS) for GTEx 49tissues
Gene ID
Gene Symbol
TSS Distance
Whole Blood
Muscle Skeletal
Liver
Brain Cerebellum
Prostate
Spleen
Skin Sun Exposed Lower leg
Artery Coronary
Esophagus Muscularis
Esophagus Gastroesophageal Junction
Artery Tibial
Heart Atrial Appendage
Nerve Tibial
Heart Left Ventricle
Adrenal Gland
Adipose Visceral Omentum
Pancreas
Lung
Pituitary
Brain Nucleus accumbens basal ganglia
Colon Transverse
Adipose Subcutaneous
Esophagus Mucosa
Brain Cortex
Thyroid
Stomach
Breast Mammary Tissue
Colon Sigmoid
Skin Not Sun Exposed Suprapubic
Testis
Artery Aorta
Brain Amygdala
Brain Anterior cingulate cortex BA24
Brain Caudate basal ganglia
Brain Cerebellar Hemisphere
Brain Frontal Cortex BA9
Brain Hippocampus
Brain Hypothalamus
Brain Putamen basal ganglia
Brain Spinal cord cervical c-1
Brain Substantia nigra
Cells Cultured fibroblasts
Cells EBV-transformed lymphocytes
Kidney Cortex
Minor Salivary Gland
Ovary
Small Intestine Terminal Ileum
Uterus
Vagina
ENSG00000116675 DNAJC6 399758 1.29e-06 1.55e-06 3.43e-07 1.27e-06 3.73e-07 6.28e-07 1.29e-06 3.9e-07 2.74e-06 1.17e-06 7.55e-06 2.2e-06 5.41e-06 1.16e-06 4.31e-07 1.51e-06 7.47e-07 9.65e-07 8.34e-07 2.65e-07 5.61e-07 4.53e-06 9.18e-07 5.01e-07 2.41e-06 7.46e-07 1.01e-06 1.81e-06 1.62e-06 1.4e-06 2.03e-06 3.68e-08 5.78e-08 5.82e-07 7.4e-07 1.54e-07 3.37e-07 1.06e-07 3.43e-07 9.81e-09 8.55e-08 2.23e-06 2.63e-08 2.69e-07 8.06e-08 3.14e-07 1.24e-07 3.14e-09 4.8e-08