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Genes within 1Mb (chr1:65614586:T:A):

View on , UCSC , GTEx , gnomAD

Immune cell-type specific single cell cis-eQTLs in OASIS
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 546832 sc-eQTL 3.46e-01 0.0612 0.0648 0.759 B L1
ENSG00000184588 PDE4B -177928 sc-eQTL 8.03e-02 0.118 0.0673 0.759 B L1
ENSG00000213625 LEPROT 193999 sc-eQTL 4.78e-01 0.0588 0.0828 0.759 B L1
ENSG00000162434 JAK1 546832 sc-eQTL 3.28e-01 0.0614 0.0626 0.759 CD4T L1
ENSG00000184588 PDE4B -177928 sc-eQTL 1.51e-01 0.107 0.0745 0.759 CD4T L1
ENSG00000213625 LEPROT 193999 sc-eQTL 6.40e-02 0.181 0.0973 0.759 CD4T L1
ENSG00000116678 LEPR 193934 sc-eQTL 1.04e-01 0.171 0.105 0.759 CD8T L1
ENSG00000162434 JAK1 546832 sc-eQTL 8.18e-01 0.0189 0.0819 0.759 CD8T L1
ENSG00000184588 PDE4B -177928 sc-eQTL 4.78e-02 0.138 0.0692 0.759 CD8T L1
ENSG00000213625 LEPROT 193999 sc-eQTL 4.07e-01 0.09 0.108 0.759 CD8T L1
ENSG00000116678 LEPR 193934 sc-eQTL 7.24e-01 -0.0397 0.113 0.757 DC L1
ENSG00000162433 AK4 467037 sc-eQTL 1.86e-01 -0.125 0.0942 0.757 DC L1
ENSG00000162434 JAK1 546832 sc-eQTL 7.35e-01 -0.0266 0.0787 0.757 DC L1
ENSG00000162437 RAVER2 869491 sc-eQTL 7.54e-01 0.0317 0.101 0.757 DC L1
ENSG00000184588 PDE4B -177928 sc-eQTL 1.95e-01 0.079 0.0607 0.757 DC L1
ENSG00000213625 LEPROT 193999 sc-eQTL 7.72e-01 0.0323 0.112 0.757 DC L1
ENSG00000285079 AL513493.1 -89376 sc-eQTL 4.93e-04 -0.207 0.0583 0.757 DC L1
ENSG00000116678 LEPR 193934 sc-eQTL 3.26e-01 0.104 0.105 0.759 Mono L1
ENSG00000162433 AK4 467037 sc-eQTL 9.21e-01 -0.00954 0.0967 0.759 Mono L1
ENSG00000162434 JAK1 546832 sc-eQTL 8.53e-01 -0.0128 0.0689 0.759 Mono L1
ENSG00000184588 PDE4B -177928 sc-eQTL 7.77e-01 -0.0108 0.0381 0.759 Mono L1
ENSG00000213625 LEPROT 193999 sc-eQTL 6.68e-01 0.0293 0.0682 0.759 Mono L1
ENSG00000116678 LEPR 193934 sc-eQTL 6.11e-01 -0.0524 0.103 0.76 NK L1
ENSG00000162434 JAK1 546832 sc-eQTL 4.26e-01 0.0388 0.0486 0.76 NK L1
ENSG00000184588 PDE4B -177928 sc-eQTL 5.05e-03 0.185 0.0651 0.76 NK L1
ENSG00000213625 LEPROT 193999 sc-eQTL 7.31e-01 -0.0382 0.111 0.76 NK L1
ENSG00000162434 JAK1 546832 sc-eQTL 5.57e-01 -0.0414 0.0703 0.759 Other_T L1
ENSG00000162437 RAVER2 869491 sc-eQTL 4.76e-01 -0.0729 0.102 0.759 Other_T L1
ENSG00000184588 PDE4B -177928 sc-eQTL 8.90e-02 0.13 0.0759 0.759 Other_T L1
ENSG00000213625 LEPROT 193999 sc-eQTL 8.97e-01 0.0144 0.11 0.759 Other_T L1
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 546832 sc-eQTL 5.43e-01 -0.073 0.12 0.783 B_Activated L2
ENSG00000184588 PDE4B -177928 sc-eQTL 6.06e-02 0.178 0.0942 0.783 B_Activated L2
ENSG00000213625 LEPROT 193999 sc-eQTL 2.49e-01 0.144 0.125 0.783 B_Activated L2
ENSG00000162434 JAK1 546832 sc-eQTL 8.73e-01 0.0148 0.0923 0.76 B_Intermediate L2
ENSG00000184588 PDE4B -177928 sc-eQTL 4.39e-01 0.0582 0.0751 0.76 B_Intermediate L2
ENSG00000213625 LEPROT 193999 sc-eQTL 9.95e-01 -0.000659 0.108 0.76 B_Intermediate L2
ENSG00000162434 JAK1 546832 sc-eQTL 4.44e-01 -0.0703 0.0918 0.756 B_Memory L2
ENSG00000184588 PDE4B -177928 sc-eQTL 2.28e-01 0.113 0.0936 0.756 B_Memory L2
ENSG00000213625 LEPROT 193999 sc-eQTL 8.09e-01 0.0258 0.107 0.756 B_Memory L2
ENSG00000162434 JAK1 546832 sc-eQTL 9.72e-01 0.00291 0.0825 0.759 B_Naive1 L2
ENSG00000184588 PDE4B -177928 sc-eQTL 1.66e-02 0.189 0.0784 0.759 B_Naive1 L2
ENSG00000213625 LEPROT 193999 sc-eQTL 3.13e-01 0.108 0.107 0.759 B_Naive1 L2
ENSG00000162434 JAK1 546832 sc-eQTL 5.52e-01 0.0514 0.0864 0.758 B_Naive2 L2
ENSG00000184588 PDE4B -177928 sc-eQTL 3.35e-02 0.145 0.0676 0.758 B_Naive2 L2
ENSG00000213625 LEPROT 193999 sc-eQTL 6.48e-01 -0.0476 0.104 0.758 B_Naive2 L2
ENSG00000162434 JAK1 546832 sc-eQTL 7.54e-01 0.0315 0.101 0.759 CD4_CTL L2
ENSG00000184588 PDE4B -177928 sc-eQTL 1.82e-02 0.209 0.0877 0.759 CD4_CTL L2
ENSG00000213625 LEPROT 193999 sc-eQTL 6.57e-01 0.0514 0.115 0.759 CD4_CTL L2
ENSG00000162434 JAK1 546832 sc-eQTL 2.74e-01 0.0672 0.0613 0.759 CD4_Naive L2
ENSG00000184588 PDE4B -177928 sc-eQTL 3.28e-01 0.0753 0.0768 0.759 CD4_Naive L2
ENSG00000213625 LEPROT 193999 sc-eQTL 2.02e-01 0.127 0.0993 0.759 CD4_Naive L2
ENSG00000162434 JAK1 546832 sc-eQTL 5.17e-01 0.0454 0.0701 0.759 CD4_TCM L2
ENSG00000184588 PDE4B -177928 sc-eQTL 1.63e-02 0.192 0.0792 0.759 CD4_TCM L2
ENSG00000213625 LEPROT 193999 sc-eQTL 3.66e-02 0.212 0.101 0.759 CD4_TCM L2
ENSG00000162434 JAK1 546832 sc-eQTL 3.74e-01 -0.084 0.0943 0.759 CD4_TEM L2
ENSG00000184588 PDE4B -177928 sc-eQTL 1.55e-01 0.124 0.0869 0.759 CD4_TEM L2
ENSG00000213625 LEPROT 193999 sc-eQTL 2.01e-01 0.143 0.112 0.759 CD4_TEM L2
ENSG00000116678 LEPR 193934 sc-eQTL 1.59e-01 0.146 0.104 0.759 CD8_CTL L2
ENSG00000162434 JAK1 546832 sc-eQTL 9.14e-01 -0.00947 0.0874 0.759 CD8_CTL L2
ENSG00000184588 PDE4B -177928 sc-eQTL 9.44e-03 0.208 0.0795 0.759 CD8_CTL L2
ENSG00000213625 LEPROT 193999 sc-eQTL 4.50e-02 0.213 0.106 0.759 CD8_CTL L2
ENSG00000116678 LEPR 193934 sc-eQTL 4.66e-01 0.0764 0.105 0.759 CD8_Naive L2
ENSG00000162434 JAK1 546832 sc-eQTL 7.11e-01 0.0324 0.0874 0.759 CD8_Naive L2
ENSG00000184588 PDE4B -177928 sc-eQTL 2.13e-01 0.0913 0.0732 0.759 CD8_Naive L2
ENSG00000213625 LEPROT 193999 sc-eQTL 3.38e-01 -0.103 0.107 0.759 CD8_Naive L2
ENSG00000116678 LEPR 193934 sc-eQTL 7.40e-01 0.0354 0.107 0.759 CD8_TCM L2
ENSG00000162434 JAK1 546832 sc-eQTL 9.09e-01 0.0107 0.0926 0.759 CD8_TCM L2
ENSG00000184588 PDE4B -177928 sc-eQTL 8.03e-01 0.0255 0.102 0.759 CD8_TCM L2
ENSG00000213625 LEPROT 193999 sc-eQTL 8.96e-01 -0.0152 0.116 0.759 CD8_TCM L2
ENSG00000116678 LEPR 193934 sc-eQTL 7.94e-01 -0.0257 0.0981 0.758 CD8_TEM L2
ENSG00000162434 JAK1 546832 sc-eQTL 4.77e-02 0.219 0.11 0.758 CD8_TEM L2
ENSG00000184588 PDE4B -177928 sc-eQTL 5.75e-02 0.179 0.0935 0.758 CD8_TEM L2
ENSG00000213625 LEPROT 193999 sc-eQTL 5.25e-01 -0.0728 0.114 0.758 CD8_TEM L2
ENSG00000162434 JAK1 546832 sc-eQTL 7.37e-01 -0.0318 0.0946 0.76 MAIT L2
ENSG00000162437 RAVER2 869491 sc-eQTL 9.67e-01 -0.00421 0.101 0.76 MAIT L2
ENSG00000184588 PDE4B -177928 sc-eQTL 4.58e-02 0.161 0.0802 0.76 MAIT L2
ENSG00000213625 LEPROT 193999 sc-eQTL 9.72e-01 0.00389 0.109 0.76 MAIT L2
ENSG00000116678 LEPR 193934 sc-eQTL 2.43e-02 -0.227 0.1 0.76 NK_CD56bright L2
ENSG00000162434 JAK1 546832 sc-eQTL 6.54e-01 -0.0311 0.0693 0.76 NK_CD56bright L2
ENSG00000184588 PDE4B -177928 sc-eQTL 4.08e-02 0.17 0.0824 0.76 NK_CD56bright L2
ENSG00000213625 LEPROT 193999 sc-eQTL 5.05e-01 -0.0759 0.114 0.76 NK_CD56bright L2
ENSG00000116678 LEPR 193934 sc-eQTL 5.83e-01 -0.06 0.109 0.763 NK_CD56dim L2
ENSG00000162434 JAK1 546832 sc-eQTL 2.44e-01 0.0663 0.0568 0.763 NK_CD56dim L2
ENSG00000184588 PDE4B -177928 sc-eQTL 1.64e-01 0.116 0.0828 0.763 NK_CD56dim L2
ENSG00000213625 LEPROT 193999 sc-eQTL 5.98e-01 0.0608 0.115 0.763 NK_CD56dim L2
ENSG00000116678 LEPR 193934 sc-eQTL 2.53e-01 0.11 0.0962 0.765 NK_HLA L2
ENSG00000162434 JAK1 546832 sc-eQTL 8.60e-02 -0.129 0.0745 0.765 NK_HLA L2
ENSG00000184588 PDE4B -177928 sc-eQTL 3.86e-02 0.188 0.0905 0.765 NK_HLA L2
ENSG00000213625 LEPROT 193999 sc-eQTL 2.44e-01 0.136 0.116 0.765 NK_HLA L2
ENSG00000116678 LEPR 193934 sc-eQTL 9.94e-01 -0.000821 0.105 0.763 NK_cytokine L2
ENSG00000162434 JAK1 546832 sc-eQTL 7.23e-01 0.0218 0.0614 0.763 NK_cytokine L2
ENSG00000184588 PDE4B -177928 sc-eQTL 8.65e-03 0.251 0.0947 0.763 NK_cytokine L2
ENSG00000213625 LEPROT 193999 sc-eQTL 3.86e-02 -0.23 0.111 0.763 NK_cytokine L2
ENSG00000162434 JAK1 546832 sc-eQTL 6.19e-01 0.052 0.104 0.77 PB L2
ENSG00000184588 PDE4B -177928 sc-eQTL 8.60e-01 0.0233 0.132 0.77 PB L2
ENSG00000213625 LEPROT 193999 sc-eQTL 7.07e-01 -0.055 0.146 0.77 PB L2
ENSG00000162434 JAK1 546832 sc-eQTL 5.56e-01 -0.0412 0.0699 0.759 Pro_T L2
ENSG00000162437 RAVER2 869491 sc-eQTL 7.93e-01 -0.0243 0.0922 0.759 Pro_T L2
ENSG00000184588 PDE4B -177928 sc-eQTL 9.47e-01 -0.00566 0.0858 0.759 Pro_T L2
ENSG00000213625 LEPROT 193999 sc-eQTL 5.80e-01 0.0603 0.109 0.759 Pro_T L2
ENSG00000162434 JAK1 546832 sc-eQTL 2.87e-01 -0.0944 0.0885 0.759 Treg L2
ENSG00000184588 PDE4B -177928 sc-eQTL 2.26e-01 0.0981 0.0807 0.759 Treg L2
ENSG00000213625 LEPROT 193999 sc-eQTL 7.93e-01 -0.0303 0.115 0.759 Treg L2
ENSG00000116678 LEPR 193934 sc-eQTL 6.72e-01 -0.0479 0.113 0.768 cDC L2
ENSG00000162433 AK4 467037 sc-eQTL 3.02e-01 -0.103 0.0995 0.768 cDC L2
ENSG00000162434 JAK1 546832 sc-eQTL 9.80e-01 -0.00231 0.0931 0.768 cDC L2
ENSG00000162437 RAVER2 869491 sc-eQTL 7.14e-01 0.0376 0.102 0.768 cDC L2
ENSG00000184588 PDE4B -177928 sc-eQTL 8.03e-01 0.0156 0.0625 0.768 cDC L2
ENSG00000213625 LEPROT 193999 sc-eQTL 6.15e-01 0.0571 0.113 0.768 cDC L2
ENSG00000285079 AL513493.1 -89376 sc-eQTL 7.86e-01 0.0111 0.0408 0.768 cDC L2
ENSG00000116678 LEPR 193934 sc-eQTL 1.51e-01 0.154 0.107 0.759 cMono_IL1B L2
ENSG00000162433 AK4 467037 sc-eQTL 4.73e-01 0.0708 0.0984 0.759 cMono_IL1B L2
ENSG00000162434 JAK1 546832 sc-eQTL 8.49e-01 0.017 0.0896 0.759 cMono_IL1B L2
ENSG00000184588 PDE4B -177928 sc-eQTL 9.99e-01 7.91e-05 0.0497 0.759 cMono_IL1B L2
ENSG00000213625 LEPROT 193999 sc-eQTL 7.40e-01 -0.0241 0.0724 0.759 cMono_IL1B L2
ENSG00000116678 LEPR 193934 sc-eQTL 6.95e-01 -0.0407 0.104 0.759 cMono_S100A L2
ENSG00000162433 AK4 467037 sc-eQTL 8.47e-01 0.019 0.0986 0.759 cMono_S100A L2
ENSG00000162434 JAK1 546832 sc-eQTL 8.82e-01 -0.0135 0.091 0.759 cMono_S100A L2
ENSG00000184588 PDE4B -177928 sc-eQTL 6.09e-01 0.0263 0.0514 0.759 cMono_S100A L2
ENSG00000213625 LEPROT 193999 sc-eQTL 2.99e-01 0.0884 0.0849 0.759 cMono_S100A L2
ENSG00000162434 JAK1 546832 sc-eQTL 7.03e-01 0.0513 0.134 0.761 gdT L2
ENSG00000162437 RAVER2 869491 sc-eQTL 4.95e-01 0.0807 0.118 0.761 gdT L2
ENSG00000184588 PDE4B -177928 sc-eQTL 2.47e-01 0.0905 0.0778 0.761 gdT L2
ENSG00000213625 LEPROT 193999 sc-eQTL 4.81e-01 0.0999 0.141 0.761 gdT L2
ENSG00000116678 LEPR 193934 sc-eQTL 2.97e-01 0.112 0.107 0.764 intMono L2
ENSG00000162433 AK4 467037 sc-eQTL 3.04e-01 -0.104 0.101 0.764 intMono L2
ENSG00000162434 JAK1 546832 sc-eQTL 9.05e-02 -0.158 0.0928 0.764 intMono L2
ENSG00000184588 PDE4B -177928 sc-eQTL 7.43e-01 0.0177 0.054 0.764 intMono L2
ENSG00000213625 LEPROT 193999 sc-eQTL 8.45e-01 -0.0176 0.0901 0.764 intMono L2
ENSG00000116678 LEPR 193934 sc-eQTL 7.09e-01 0.0392 0.105 0.767 ncMono L2
ENSG00000162433 AK4 467037 sc-eQTL 4.78e-02 -0.184 0.0926 0.767 ncMono L2
ENSG00000162434 JAK1 546832 sc-eQTL 8.18e-02 0.131 0.0751 0.767 ncMono L2
ENSG00000184588 PDE4B -177928 sc-eQTL 9.13e-01 0.00661 0.0601 0.767 ncMono L2
ENSG00000213625 LEPROT 193999 sc-eQTL 2.71e-01 0.118 0.107 0.767 ncMono L2
ENSG00000116678 LEPR 193934 sc-eQTL 2.19e-01 -0.136 0.11 0.763 pDC L2
ENSG00000162433 AK4 467037 sc-eQTL 8.97e-01 -0.00935 0.072 0.763 pDC L2
ENSG00000162434 JAK1 546832 sc-eQTL 9.38e-01 -0.00744 0.0961 0.763 pDC L2
ENSG00000162437 RAVER2 869491 sc-eQTL 6.68e-01 0.0464 0.108 0.763 pDC L2
ENSG00000184588 PDE4B -177928 sc-eQTL 4.81e-01 0.0592 0.0837 0.763 pDC L2
ENSG00000213625 LEPROT 193999 sc-eQTL 2.84e-02 0.26 0.117 0.763 pDC L2
ENSG00000285079 AL513493.1 -89376 sc-eQTL 7.28e-04 -0.299 0.0868 0.763 pDC L2
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 546832 sc-eQTL 7.49e-01 0.0264 0.0823 0.759 B_Memory LOneK1K
ENSG00000184588 PDE4B -177928 sc-eQTL 1.58e-01 0.0953 0.0673 0.759 B_Memory LOneK1K
ENSG00000213625 LEPROT 193999 sc-eQTL 6.78e-01 0.0439 0.106 0.759 B_Memory LOneK1K
ENSG00000162434 JAK1 546832 sc-eQTL 6.89e-01 0.032 0.0798 0.759 B_Naive LOneK1K
ENSG00000184588 PDE4B -177928 sc-eQTL 1.07e-02 0.182 0.0706 0.759 B_Naive LOneK1K
ENSG00000213625 LEPROT 193999 sc-eQTL 4.12e-01 0.0828 0.101 0.759 B_Naive LOneK1K
ENSG00000116678 LEPR 193934 sc-eQTL 2.97e-01 0.109 0.104 0.759 CD14_Mono LOneK1K
ENSG00000162433 AK4 467037 sc-eQTL 7.55e-01 0.0312 0.0999 0.759 CD14_Mono LOneK1K
ENSG00000162434 JAK1 546832 sc-eQTL 8.23e-01 -0.0187 0.0836 0.759 CD14_Mono LOneK1K
ENSG00000184588 PDE4B -177928 sc-eQTL 8.56e-01 0.00775 0.0426 0.759 CD14_Mono LOneK1K
ENSG00000213625 LEPROT 193999 sc-eQTL 9.37e-01 -0.00553 0.0701 0.759 CD14_Mono LOneK1K
ENSG00000116678 LEPR 193934 sc-eQTL 2.73e-01 0.117 0.106 0.761 CD16_Mono LOneK1K
ENSG00000162433 AK4 467037 sc-eQTL 4.45e-01 -0.0739 0.0966 0.761 CD16_Mono LOneK1K
ENSG00000162434 JAK1 546832 sc-eQTL 9.96e-01 -0.000291 0.0651 0.761 CD16_Mono LOneK1K
ENSG00000184588 PDE4B -177928 sc-eQTL 8.97e-01 0.00644 0.0497 0.761 CD16_Mono LOneK1K
ENSG00000213625 LEPROT 193999 sc-eQTL 1.46e-01 0.132 0.0903 0.761 CD16_Mono LOneK1K
ENSG00000116678 LEPR 193934 sc-eQTL 8.42e-01 -0.0212 0.106 0.763 NK_CD56dim LOneK1K
ENSG00000162434 JAK1 546832 sc-eQTL 3.53e-01 0.0462 0.0497 0.763 NK_CD56dim LOneK1K
ENSG00000184588 PDE4B -177928 sc-eQTL 1.63e-02 0.185 0.0762 0.763 NK_CD56dim LOneK1K
ENSG00000213625 LEPROT 193999 sc-eQTL 5.78e-01 -0.0614 0.11 0.763 NK_CD56dim LOneK1K

Statistical fine-mapping results from Japan COVID-19 Task Force
(Shown only for PIP>0.001)
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
PIP (SuSiE)
PIP (FINEMAP)
MAF
ENSG00000116675 DNAJC6 366367 eQTL 0.0287 -0.0732 0.0334 0.00117 0.0 0.281
ENSG00000116678 LEPR 193934 eQTL 0.361 -0.0231 0.0253 0.00769 0.00437 0.281
ENSG00000213625 LEPROT 193999 eQTL 0.00845 0.0556 0.0211 0.0 0.0 0.281

Expression Modifier Score(EMS) for GTEx 49tissues
Gene ID
Gene Symbol
TSS Distance
Whole Blood
Muscle Skeletal
Liver
Brain Cerebellum
Prostate
Spleen
Skin Sun Exposed Lower leg
Artery Coronary
Esophagus Muscularis
Esophagus Gastroesophageal Junction
Artery Tibial
Heart Atrial Appendage
Nerve Tibial
Heart Left Ventricle
Adrenal Gland
Adipose Visceral Omentum
Pancreas
Lung
Pituitary
Brain Nucleus accumbens basal ganglia
Colon Transverse
Adipose Subcutaneous
Esophagus Mucosa
Brain Cortex
Thyroid
Stomach
Breast Mammary Tissue
Colon Sigmoid
Skin Not Sun Exposed Suprapubic
Testis
Artery Aorta
Brain Amygdala
Brain Anterior cingulate cortex BA24
Brain Caudate basal ganglia
Brain Cerebellar Hemisphere
Brain Frontal Cortex BA9
Brain Hippocampus
Brain Hypothalamus
Brain Putamen basal ganglia
Brain Spinal cord cervical c-1
Brain Substantia nigra
Cells Cultured fibroblasts
Cells EBV-transformed lymphocytes
Kidney Cortex
Minor Salivary Gland
Ovary
Small Intestine Terminal Ileum
Uterus
Vagina
ENSG00000116675 DNAJC6 366367 1.24e-06 9.45e-07 3.27e-07 4.19e-07 2.76e-07 4.35e-07 9.74e-07 3.28e-07 1.13e-06 3.82e-07 1.36e-06 5.71e-07 1.46e-06 2.54e-07 4.31e-07 6.35e-07 7.72e-07 5.72e-07 5.36e-07 6.97e-07 3.99e-07 1.05e-06 6.63e-07 5.36e-07 1.79e-06 2.99e-07 7.12e-07 7.19e-07 9.15e-07 9.57e-07 5.1e-07 9.54e-08 1.98e-07 3.82e-07 3.92e-07 3.59e-07 3.65e-07 1.47e-07 1.71e-07 1.3e-07 2.92e-07 1.09e-06 5.62e-08 2.71e-08 1.67e-07 1.27e-07 2.34e-07 8.25e-08 1.04e-07