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Genes within 1Mb (chr1:65610675:C:T):

View on , UCSC , GTEx , gnomAD

Immune cell-type specific single cell cis-eQTLs in OASIS
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 542921 sc-eQTL 2.88e-01 0.0681 0.064 0.746 B L1
ENSG00000184588 PDE4B -181839 sc-eQTL 9.78e-02 0.111 0.0665 0.746 B L1
ENSG00000213625 LEPROT 190088 sc-eQTL 5.03e-01 0.0549 0.0818 0.746 B L1
ENSG00000162434 JAK1 542921 sc-eQTL 4.63e-01 0.0457 0.0621 0.746 CD4T L1
ENSG00000184588 PDE4B -181839 sc-eQTL 1.90e-01 0.0971 0.0738 0.746 CD4T L1
ENSG00000213625 LEPROT 190088 sc-eQTL 6.31e-02 0.18 0.0964 0.746 CD4T L1
ENSG00000116678 LEPR 190023 sc-eQTL 1.69e-01 0.143 0.104 0.746 CD8T L1
ENSG00000162434 JAK1 542921 sc-eQTL 6.14e-01 0.0408 0.0808 0.746 CD8T L1
ENSG00000184588 PDE4B -181839 sc-eQTL 3.63e-02 0.144 0.0683 0.746 CD8T L1
ENSG00000213625 LEPROT 190088 sc-eQTL 3.39e-01 0.102 0.107 0.746 CD8T L1
ENSG00000116678 LEPR 190023 sc-eQTL 8.04e-01 -0.0274 0.11 0.743 DC L1
ENSG00000162433 AK4 463126 sc-eQTL 1.07e-01 -0.149 0.0921 0.743 DC L1
ENSG00000162434 JAK1 542921 sc-eQTL 7.14e-01 -0.0283 0.0771 0.743 DC L1
ENSG00000162437 RAVER2 865580 sc-eQTL 9.97e-01 -0.00039 0.0988 0.743 DC L1
ENSG00000184588 PDE4B -181839 sc-eQTL 2.61e-01 0.0672 0.0596 0.743 DC L1
ENSG00000213625 LEPROT 190088 sc-eQTL 7.99e-01 0.0278 0.109 0.743 DC L1
ENSG00000285079 AL513493.1 -93287 sc-eQTL 1.81e-04 -0.217 0.0568 0.743 DC L1
ENSG00000116678 LEPR 190023 sc-eQTL 5.06e-01 0.0699 0.105 0.746 Mono L1
ENSG00000162433 AK4 463126 sc-eQTL 9.76e-01 -0.00288 0.0961 0.746 Mono L1
ENSG00000162434 JAK1 542921 sc-eQTL 8.53e-01 -0.0127 0.0686 0.746 Mono L1
ENSG00000184588 PDE4B -181839 sc-eQTL 8.23e-01 0.00848 0.0379 0.746 Mono L1
ENSG00000213625 LEPROT 190088 sc-eQTL 4.24e-01 0.0543 0.0678 0.746 Mono L1
ENSG00000116678 LEPR 190023 sc-eQTL 5.22e-01 -0.0653 0.102 0.747 NK L1
ENSG00000162434 JAK1 542921 sc-eQTL 4.59e-01 0.0357 0.0481 0.747 NK L1
ENSG00000184588 PDE4B -181839 sc-eQTL 2.25e-03 0.199 0.0642 0.747 NK L1
ENSG00000213625 LEPROT 190088 sc-eQTL 8.26e-01 -0.0242 0.11 0.747 NK L1
ENSG00000162434 JAK1 542921 sc-eQTL 5.78e-01 -0.0387 0.0694 0.746 Other_T L1
ENSG00000162437 RAVER2 865580 sc-eQTL 5.45e-01 -0.0611 0.101 0.746 Other_T L1
ENSG00000184588 PDE4B -181839 sc-eQTL 6.15e-02 0.141 0.0748 0.746 Other_T L1
ENSG00000213625 LEPROT 190088 sc-eQTL 9.56e-01 0.00602 0.109 0.746 Other_T L1
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 542921 sc-eQTL 4.31e-01 -0.0949 0.12 0.77 B_Activated L2
ENSG00000184588 PDE4B -181839 sc-eQTL 3.32e-02 0.203 0.0943 0.77 B_Activated L2
ENSG00000213625 LEPROT 190088 sc-eQTL 3.94e-01 0.107 0.126 0.77 B_Activated L2
ENSG00000162434 JAK1 542921 sc-eQTL 8.15e-01 0.0214 0.0912 0.747 B_Intermediate L2
ENSG00000184588 PDE4B -181839 sc-eQTL 4.98e-01 0.0505 0.0743 0.747 B_Intermediate L2
ENSG00000213625 LEPROT 190088 sc-eQTL 9.09e-01 0.0122 0.107 0.747 B_Intermediate L2
ENSG00000162434 JAK1 542921 sc-eQTL 5.30e-01 -0.0571 0.0909 0.744 B_Memory L2
ENSG00000184588 PDE4B -181839 sc-eQTL 2.51e-01 0.107 0.0926 0.744 B_Memory L2
ENSG00000213625 LEPROT 190088 sc-eQTL 7.42e-01 0.0348 0.106 0.744 B_Memory L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.74e-01 0.0235 0.0815 0.746 B_Naive1 L2
ENSG00000184588 PDE4B -181839 sc-eQTL 3.58e-02 0.164 0.0778 0.746 B_Naive1 L2
ENSG00000213625 LEPROT 190088 sc-eQTL 4.96e-01 0.0724 0.106 0.746 B_Naive1 L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.29e-01 0.0297 0.0856 0.745 B_Naive2 L2
ENSG00000184588 PDE4B -181839 sc-eQTL 3.58e-02 0.142 0.067 0.745 B_Naive2 L2
ENSG00000213625 LEPROT 190088 sc-eQTL 7.68e-01 -0.0304 0.103 0.745 B_Naive2 L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.61e-01 0.0305 0.1 0.745 CD4_CTL L2
ENSG00000184588 PDE4B -181839 sc-eQTL 2.92e-02 0.192 0.0875 0.745 CD4_CTL L2
ENSG00000213625 LEPROT 190088 sc-eQTL 8.88e-01 0.0162 0.115 0.745 CD4_CTL L2
ENSG00000162434 JAK1 542921 sc-eQTL 4.41e-01 0.0468 0.0607 0.746 CD4_Naive L2
ENSG00000184588 PDE4B -181839 sc-eQTL 3.71e-01 0.0681 0.0759 0.746 CD4_Naive L2
ENSG00000213625 LEPROT 190088 sc-eQTL 2.63e-01 0.11 0.0983 0.746 CD4_Naive L2
ENSG00000162434 JAK1 542921 sc-eQTL 4.10e-01 0.0574 0.0695 0.746 CD4_TCM L2
ENSG00000184588 PDE4B -181839 sc-eQTL 1.83e-02 0.187 0.0787 0.746 CD4_TCM L2
ENSG00000213625 LEPROT 190088 sc-eQTL 2.56e-02 0.224 0.0998 0.746 CD4_TCM L2
ENSG00000162434 JAK1 542921 sc-eQTL 4.58e-01 -0.0695 0.0934 0.746 CD4_TEM L2
ENSG00000184588 PDE4B -181839 sc-eQTL 1.20e-01 0.134 0.0859 0.746 CD4_TEM L2
ENSG00000213625 LEPROT 190088 sc-eQTL 1.64e-01 0.154 0.11 0.746 CD4_TEM L2
ENSG00000116678 LEPR 190023 sc-eQTL 1.40e-01 0.152 0.103 0.746 CD8_CTL L2
ENSG00000162434 JAK1 542921 sc-eQTL 9.70e-01 0.00321 0.0865 0.746 CD8_CTL L2
ENSG00000184588 PDE4B -181839 sc-eQTL 1.82e-02 0.188 0.079 0.746 CD8_CTL L2
ENSG00000213625 LEPROT 190088 sc-eQTL 1.45e-02 0.257 0.104 0.746 CD8_CTL L2
ENSG00000116678 LEPR 190023 sc-eQTL 6.32e-01 0.0496 0.103 0.746 CD8_Naive L2
ENSG00000162434 JAK1 542921 sc-eQTL 6.60e-01 0.038 0.0862 0.746 CD8_Naive L2
ENSG00000184588 PDE4B -181839 sc-eQTL 1.24e-01 0.111 0.0721 0.746 CD8_Naive L2
ENSG00000213625 LEPROT 190088 sc-eQTL 3.33e-01 -0.102 0.105 0.746 CD8_Naive L2
ENSG00000116678 LEPR 190023 sc-eQTL 7.48e-01 0.0338 0.105 0.745 CD8_TCM L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.74e-01 -0.0263 0.0914 0.745 CD8_TCM L2
ENSG00000184588 PDE4B -181839 sc-eQTL 4.93e-01 0.0689 0.1 0.745 CD8_TCM L2
ENSG00000213625 LEPROT 190088 sc-eQTL 7.04e-01 0.0434 0.114 0.745 CD8_TCM L2
ENSG00000116678 LEPR 190023 sc-eQTL 9.07e-01 0.0113 0.0966 0.747 CD8_TEM L2
ENSG00000162434 JAK1 542921 sc-eQTL 1.01e-01 0.179 0.108 0.747 CD8_TEM L2
ENSG00000184588 PDE4B -181839 sc-eQTL 4.95e-02 0.182 0.092 0.747 CD8_TEM L2
ENSG00000213625 LEPROT 190088 sc-eQTL 5.42e-01 -0.0687 0.112 0.747 CD8_TEM L2
ENSG00000162434 JAK1 542921 sc-eQTL 5.09e-01 -0.0621 0.094 0.747 MAIT L2
ENSG00000162437 RAVER2 865580 sc-eQTL 9.45e-01 0.00693 0.1 0.747 MAIT L2
ENSG00000184588 PDE4B -181839 sc-eQTL 1.49e-02 0.195 0.0793 0.747 MAIT L2
ENSG00000213625 LEPROT 190088 sc-eQTL 4.79e-01 0.0767 0.108 0.747 MAIT L2
ENSG00000116678 LEPR 190023 sc-eQTL 1.29e-02 -0.248 0.0989 0.747 NK_CD56bright L2
ENSG00000162434 JAK1 542921 sc-eQTL 8.67e-01 -0.0115 0.0688 0.747 NK_CD56bright L2
ENSG00000184588 PDE4B -181839 sc-eQTL 2.26e-02 0.187 0.0815 0.747 NK_CD56bright L2
ENSG00000213625 LEPROT 190088 sc-eQTL 6.68e-01 -0.0485 0.113 0.747 NK_CD56bright L2
ENSG00000116678 LEPR 190023 sc-eQTL 3.58e-01 -0.0992 0.108 0.75 NK_CD56dim L2
ENSG00000162434 JAK1 542921 sc-eQTL 3.07e-01 0.0575 0.0562 0.75 NK_CD56dim L2
ENSG00000184588 PDE4B -181839 sc-eQTL 1.06e-01 0.133 0.0818 0.75 NK_CD56dim L2
ENSG00000213625 LEPROT 190088 sc-eQTL 6.31e-01 0.0548 0.114 0.75 NK_CD56dim L2
ENSG00000116678 LEPR 190023 sc-eQTL 3.45e-01 0.09 0.0951 0.751 NK_HLA L2
ENSG00000162434 JAK1 542921 sc-eQTL 1.02e-01 -0.121 0.0737 0.751 NK_HLA L2
ENSG00000184588 PDE4B -181839 sc-eQTL 5.28e-02 0.174 0.0895 0.751 NK_HLA L2
ENSG00000213625 LEPROT 190088 sc-eQTL 1.36e-01 0.171 0.114 0.751 NK_HLA L2
ENSG00000116678 LEPR 190023 sc-eQTL 7.15e-01 0.0381 0.104 0.75 NK_cytokine L2
ENSG00000162434 JAK1 542921 sc-eQTL 5.65e-01 0.035 0.0607 0.75 NK_cytokine L2
ENSG00000184588 PDE4B -181839 sc-eQTL 2.28e-02 0.216 0.0941 0.75 NK_cytokine L2
ENSG00000213625 LEPROT 190088 sc-eQTL 6.49e-02 -0.203 0.11 0.75 NK_cytokine L2
ENSG00000162434 JAK1 542921 sc-eQTL 4.14e-01 0.0852 0.104 0.759 PB L2
ENSG00000184588 PDE4B -181839 sc-eQTL 6.37e-01 0.0625 0.132 0.759 PB L2
ENSG00000213625 LEPROT 190088 sc-eQTL 7.08e-01 -0.0548 0.146 0.759 PB L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.83e-01 -0.0191 0.0693 0.746 Pro_T L2
ENSG00000162437 RAVER2 865580 sc-eQTL 9.65e-01 -0.00407 0.0914 0.746 Pro_T L2
ENSG00000184588 PDE4B -181839 sc-eQTL 8.82e-01 -0.0126 0.085 0.746 Pro_T L2
ENSG00000213625 LEPROT 190088 sc-eQTL 9.94e-01 0.000772 0.108 0.746 Pro_T L2
ENSG00000162434 JAK1 542921 sc-eQTL 3.19e-01 -0.0873 0.0875 0.746 Treg L2
ENSG00000184588 PDE4B -181839 sc-eQTL 2.71e-01 0.088 0.0798 0.746 Treg L2
ENSG00000213625 LEPROT 190088 sc-eQTL 6.06e-01 0.0587 0.114 0.746 Treg L2
ENSG00000116678 LEPR 190023 sc-eQTL 7.33e-01 -0.0379 0.111 0.754 cDC L2
ENSG00000162433 AK4 463126 sc-eQTL 2.30e-01 -0.118 0.0977 0.754 cDC L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.90e-01 -0.0244 0.0915 0.754 cDC L2
ENSG00000162437 RAVER2 865580 sc-eQTL 7.99e-01 0.0257 0.101 0.754 cDC L2
ENSG00000184588 PDE4B -181839 sc-eQTL 8.92e-01 0.00833 0.0614 0.754 cDC L2
ENSG00000213625 LEPROT 190088 sc-eQTL 7.57e-01 0.0346 0.112 0.754 cDC L2
ENSG00000285079 AL513493.1 -93287 sc-eQTL 7.32e-01 0.0138 0.0401 0.754 cDC L2
ENSG00000116678 LEPR 190023 sc-eQTL 3.26e-01 0.105 0.107 0.746 cMono_IL1B L2
ENSG00000162433 AK4 463126 sc-eQTL 3.75e-01 0.0874 0.0982 0.746 cMono_IL1B L2
ENSG00000162434 JAK1 542921 sc-eQTL 9.69e-01 -0.0035 0.0894 0.746 cMono_IL1B L2
ENSG00000184588 PDE4B -181839 sc-eQTL 6.16e-01 0.0249 0.0496 0.746 cMono_IL1B L2
ENSG00000213625 LEPROT 190088 sc-eQTL 9.13e-01 -0.00794 0.0723 0.746 cMono_IL1B L2
ENSG00000116678 LEPR 190023 sc-eQTL 5.58e-01 -0.0606 0.103 0.746 cMono_S100A L2
ENSG00000162433 AK4 463126 sc-eQTL 7.50e-01 0.0313 0.0982 0.746 cMono_S100A L2
ENSG00000162434 JAK1 542921 sc-eQTL 9.43e-01 -0.00648 0.0906 0.746 cMono_S100A L2
ENSG00000184588 PDE4B -181839 sc-eQTL 4.58e-01 0.038 0.0512 0.746 cMono_S100A L2
ENSG00000213625 LEPROT 190088 sc-eQTL 1.59e-01 0.119 0.0844 0.746 cMono_S100A L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.36e-01 0.0437 0.13 0.742 gdT L2
ENSG00000162437 RAVER2 865580 sc-eQTL 3.98e-01 0.0964 0.114 0.742 gdT L2
ENSG00000184588 PDE4B -181839 sc-eQTL 3.59e-01 0.0692 0.0752 0.742 gdT L2
ENSG00000213625 LEPROT 190088 sc-eQTL 7.62e-01 -0.0415 0.137 0.742 gdT L2
ENSG00000116678 LEPR 190023 sc-eQTL 3.00e-01 0.111 0.106 0.751 intMono L2
ENSG00000162433 AK4 463126 sc-eQTL 8.51e-02 -0.173 0.0997 0.751 intMono L2
ENSG00000162434 JAK1 542921 sc-eQTL 2.02e-01 -0.118 0.0925 0.751 intMono L2
ENSG00000184588 PDE4B -181839 sc-eQTL 4.38e-01 0.0416 0.0536 0.751 intMono L2
ENSG00000213625 LEPROT 190088 sc-eQTL 7.02e-01 0.0343 0.0895 0.751 intMono L2
ENSG00000116678 LEPR 190023 sc-eQTL 7.52e-01 0.0328 0.104 0.756 ncMono L2
ENSG00000162433 AK4 463126 sc-eQTL 3.63e-02 -0.193 0.0916 0.756 ncMono L2
ENSG00000162434 JAK1 542921 sc-eQTL 7.60e-02 0.133 0.0743 0.756 ncMono L2
ENSG00000184588 PDE4B -181839 sc-eQTL 9.72e-01 0.00212 0.0595 0.756 ncMono L2
ENSG00000213625 LEPROT 190088 sc-eQTL 1.81e-01 0.142 0.106 0.756 ncMono L2
ENSG00000116678 LEPR 190023 sc-eQTL 3.63e-01 -0.0995 0.109 0.751 pDC L2
ENSG00000162433 AK4 463126 sc-eQTL 7.42e-01 -0.0235 0.0712 0.751 pDC L2
ENSG00000162434 JAK1 542921 sc-eQTL 9.66e-01 -0.00407 0.0951 0.751 pDC L2
ENSG00000162437 RAVER2 865580 sc-eQTL 7.50e-01 0.0342 0.107 0.751 pDC L2
ENSG00000184588 PDE4B -181839 sc-eQTL 5.98e-01 0.0438 0.0829 0.751 pDC L2
ENSG00000213625 LEPROT 190088 sc-eQTL 1.45e-02 0.286 0.116 0.751 pDC L2
ENSG00000285079 AL513493.1 -93287 sc-eQTL 1.28e-03 -0.283 0.0862 0.751 pDC L2
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
MAF
Cell type
Cluster resolution
ENSG00000162434 JAK1 542921 sc-eQTL 7.06e-01 0.0307 0.0813 0.746 B_Memory LOneK1K
ENSG00000184588 PDE4B -181839 sc-eQTL 1.99e-01 0.0858 0.0666 0.746 B_Memory LOneK1K
ENSG00000213625 LEPROT 190088 sc-eQTL 6.30e-01 0.0504 0.104 0.746 B_Memory LOneK1K
ENSG00000162434 JAK1 542921 sc-eQTL 6.33e-01 0.0378 0.0789 0.746 B_Naive LOneK1K
ENSG00000184588 PDE4B -181839 sc-eQTL 1.83e-02 0.166 0.07 0.746 B_Naive LOneK1K
ENSG00000213625 LEPROT 190088 sc-eQTL 5.73e-01 0.0563 0.0997 0.746 B_Naive LOneK1K
ENSG00000116678 LEPR 190023 sc-eQTL 5.73e-01 0.0587 0.104 0.746 CD14_Mono LOneK1K
ENSG00000162433 AK4 463126 sc-eQTL 5.98e-01 0.0526 0.0995 0.746 CD14_Mono LOneK1K
ENSG00000162434 JAK1 542921 sc-eQTL 7.61e-01 -0.0254 0.0833 0.746 CD14_Mono LOneK1K
ENSG00000184588 PDE4B -181839 sc-eQTL 5.66e-01 0.0244 0.0425 0.746 CD14_Mono LOneK1K
ENSG00000213625 LEPROT 190088 sc-eQTL 7.98e-01 0.0179 0.0698 0.746 CD14_Mono LOneK1K
ENSG00000116678 LEPR 190023 sc-eQTL 2.79e-01 0.115 0.106 0.748 CD16_Mono LOneK1K
ENSG00000162433 AK4 463126 sc-eQTL 1.88e-01 -0.126 0.0958 0.748 CD16_Mono LOneK1K
ENSG00000162434 JAK1 542921 sc-eQTL 6.97e-01 0.0252 0.0647 0.748 CD16_Mono LOneK1K
ENSG00000184588 PDE4B -181839 sc-eQTL 8.90e-01 0.00683 0.0495 0.748 CD16_Mono LOneK1K
ENSG00000213625 LEPROT 190088 sc-eQTL 7.41e-02 0.161 0.0896 0.748 CD16_Mono LOneK1K
ENSG00000116678 LEPR 190023 sc-eQTL 7.30e-01 -0.0363 0.105 0.75 NK_CD56dim LOneK1K
ENSG00000162434 JAK1 542921 sc-eQTL 4.00e-01 0.0416 0.0493 0.75 NK_CD56dim LOneK1K
ENSG00000184588 PDE4B -181839 sc-eQTL 8.78e-03 0.199 0.0754 0.75 NK_CD56dim LOneK1K
ENSG00000213625 LEPROT 190088 sc-eQTL 5.98e-01 -0.0577 0.109 0.75 NK_CD56dim LOneK1K

Statistical fine-mapping results from Japan COVID-19 Task Force
(Shown only for PIP>0.001)
Gene ID
Gene Symbol
TSS Distance
Category
P-value
Effect Size
Effect Size (se)
PIP (SuSiE)
PIP (FINEMAP)
MAF
ENSG00000116675 DNAJC6 362456 eQTL 0.0455 -0.0665 0.0332 0.0 0.0 0.287
ENSG00000116678 LEPR 190023 eQTL 0.505 -0.0167 0.0251 0.00305 0.00175 0.287
ENSG00000213625 LEPROT 190088 eQTL 0.00317 0.0619 0.0209 0.0 0.0 0.287

Expression Modifier Score(EMS) for GTEx 49tissues
Gene ID
Gene Symbol
TSS Distance
Whole Blood
Muscle Skeletal
Liver
Brain Cerebellum
Prostate
Spleen
Skin Sun Exposed Lower leg
Artery Coronary
Esophagus Muscularis
Esophagus Gastroesophageal Junction
Artery Tibial
Heart Atrial Appendage
Nerve Tibial
Heart Left Ventricle
Adrenal Gland
Adipose Visceral Omentum
Pancreas
Lung
Pituitary
Brain Nucleus accumbens basal ganglia
Colon Transverse
Adipose Subcutaneous
Esophagus Mucosa
Brain Cortex
Thyroid
Stomach
Breast Mammary Tissue
Colon Sigmoid
Skin Not Sun Exposed Suprapubic
Testis
Artery Aorta
Brain Amygdala
Brain Anterior cingulate cortex BA24
Brain Caudate basal ganglia
Brain Cerebellar Hemisphere
Brain Frontal Cortex BA9
Brain Hippocampus
Brain Hypothalamus
Brain Putamen basal ganglia
Brain Spinal cord cervical c-1
Brain Substantia nigra
Cells Cultured fibroblasts
Cells EBV-transformed lymphocytes
Kidney Cortex
Minor Salivary Gland
Ovary
Small Intestine Terminal Ileum
Uterus
Vagina
ENSG00000116675 DNAJC6 362456 1.17e-06 8.69e-07 1.76e-07 3.54e-07 1.56e-07 3.18e-07 7.02e-07 2.74e-07 8.7e-07 2.85e-07 1.09e-06 5.39e-07 1.23e-06 2.06e-07 4.15e-07 4.53e-07 6.29e-07 4.95e-07 3.43e-07 3.99e-07 2.72e-07 5.66e-07 5.41e-07 3.32e-07 1.53e-06 2.4e-07 5.04e-07 4.92e-07 6.47e-07 8.36e-07 4.34e-07 3.8e-08 1.04e-07 2.33e-07 3.29e-07 2.76e-07 3.14e-07 1.42e-07 1.55e-07 3.03e-08 2.19e-07 1.02e-06 5.78e-08 3.4e-08 1.85e-07 4.53e-08 1.41e-07 8.08e-08 5.55e-08